• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Generation of a subtype-specific neutralization epitope in foot-and-mouth disease virus of a different subtype.

作者信息

Hernández J, Martínez M A, Rocha E, Domingo E, Mateu M G

机构信息

Centro de Biología Molecular, Universidad Autónoma de Madrid, Spain.

出版信息

J Gen Virol. 1992 Jan;73 ( Pt 1):213-6. doi: 10.1099/0022-1317-73-1-213.

DOI:10.1099/0022-1317-73-1-213
PMID:1370534
Abstract

An epitope involved in neutralization of foot-and-mouth disease virus (FMDV) of subtype C3 was generated by a single amino acid replacement in VP1 of FMDV of subtype C1. The replacement [Ser (139)----Ile, in the immunodominant site A] was consistently found in those FMDV C1 Santa Pau-Sp/70 mutants resistant to neutralization by monoclonal antibody (MAb) SD6 (specific for most C1 viruses) that acquired the capacity to be neutralized by MAb 7AB5 (specific for C3 viruses).

摘要

相似文献

1
Generation of a subtype-specific neutralization epitope in foot-and-mouth disease virus of a different subtype.
J Gen Virol. 1992 Jan;73 ( Pt 1):213-6. doi: 10.1099/0022-1317-73-1-213.
2
Analysis of foot-and-mouth disease virus type O1 Brugge neutralization epitopes using monoclonal antibodies.利用单克隆抗体分析O1布吕赫口蹄疫病毒中和表位
J Gen Virol. 1986 Oct;67 ( Pt 10):2083-92. doi: 10.1099/0022-1317-67-10-2083.
3
Monoclonal antibodies to an Indian strain of type A foot-and-mouth disease virus.针对印度A型口蹄疫病毒毒株的单克隆抗体。
Acta Virol. 1999 Aug;43(4):219-25.
4
Host cell selection of antigenic variants of foot-and-mouth disease virus.口蹄疫病毒抗原变异株的宿主细胞选择
J Gen Virol. 1989 Jan;70 ( Pt 1):45-57. doi: 10.1099/0022-1317-70-1-45.
5
Reactivity with monoclonal antibodies of viruses from an episode of foot-and-mouth disease.口蹄疫疫情中病毒与单克隆抗体的反应性。
Virus Res. 1987 Sep;8(3):261-74. doi: 10.1016/0168-1702(87)90020-7.
6
Evidence for at least four antigenic sites on type O foot-and-mouth disease virus involved in neutralization; identification by single and multiple site monoclonal antibody-resistant mutants.O型口蹄疫病毒中至少四个参与中和作用的抗原位点的证据；通过单一位点和多位点单克隆抗体抗性突变体进行鉴定
J Gen Virol. 1989 Mar;70 ( Pt 3):639-45. doi: 10.1099/0022-1317-70-3-639.
7
Identification of a fifth neutralizable site on type O foot-and-mouth disease virus following characterization of single and quintuple monoclonal antibody escape mutants.在对单克隆和五重单克隆抗体逃逸突变体进行表征后，鉴定出O型口蹄疫病毒上的第五个可中和位点。
J Gen Virol. 1993 Aug;74 ( Pt 8):1547-53. doi: 10.1099/0022-1317-74-8-1547.
8
A protective anti-peptide antibody against the immunodominant site of the A24 Cruzeiro strain of foot-and-mouth disease virus and its reactivity with other subtype viruses containing the same minimum binding sequence.一种针对口蹄疫病毒A24克鲁塞罗株免疫显性位点的保护性抗肽抗体及其与含有相同最小结合序列的其他亚型病毒的反应性。
J Gen Virol. 1996 May;77 ( Pt 5):1011-8. doi: 10.1099/0022-1317-77-5-1011.
9
Neutralizing epitopes of type O foot-and-mouth disease virus. II. Mapping three conformational sites with synthetic peptide reagents.O型口蹄疫病毒的中和表位。II. 用合成肽试剂定位三个构象位点
J Gen Virol. 1989 Jun;70 ( Pt 6):1493-503. doi: 10.1099/0022-1317-70-6-1493.
10
Genetic and phenotypic variability during replication of foot-and-mouth disease virus in swine.口蹄疫病毒在猪体内复制过程中的遗传和表型变异性
Virology. 1990 Dec;179(2):890-2. doi: 10.1016/0042-6822(90)90162-k.

引用本文的文献

1
Genetic Basis of Antigenic Variation of SAT3 Foot-And-Mouth Disease Viruses in Southern Africa.南非SAT3型口蹄疫病毒抗原变异的遗传基础
Front Vet Sci. 2020 Sep 8;7:568. doi: 10.3389/fvets.2020.00568. eCollection 2020.
2
A simple and rapid colloidal gold-based immunochromatogarpic strip test for detection of FMDV serotype A.一种用于检测口蹄疫病毒 A 型的简单快速胶体金免疫层析试纸条检测方法。
Virol Sin. 2011 Feb;26(1):30-9. doi: 10.1007/s12250-011-3166-5. Epub 2011 Feb 18.
3
Amino acid variation within the fusion protein of respiratory syncytial virus subtype A and B strains during annual epidemics in South Africa.
南非年度流行期间呼吸道合胞病毒A、B亚型毒株融合蛋白内的氨基酸变异
Virus Genes. 2005 Mar;30(2):267-78. doi: 10.1007/s11262-004-5633-2.
4
Evolution subverting essentiality: dispensability of the cell attachment Arg-Gly-Asp motif in multiply passaged foot-and-mouth disease virus.进化颠覆必要性：多次传代的口蹄疫病毒中细胞附着性精氨酸-甘氨酸-天冬氨酸基序的非必需性
Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6798-802. doi: 10.1073/pnas.94.13.6798.
5
Molecular evolution of aphthoviruses.口蹄疫病毒的分子进化
Virus Genes. 1995;11(2-3):197-207. doi: 10.1007/BF01728659.
6
Antigenic heterogeneity of a foot-and-mouth disease virus serotype in the field is mediated by very limited sequence variation at several antigenic sites.口蹄疫病毒血清型在自然环境中的抗原异质性是由几个抗原位点上非常有限的序列变异介导的。
J Virol. 1994 Mar;68(3):1407-17. doi: 10.1128/JVI.68.3.1407-1417.1994.
7
Structure of the major antigenic loop of foot-and-mouth disease virus complexed with a neutralizing antibody: direct involvement of the Arg-Gly-Asp motif in the interaction.口蹄疫病毒主要抗原环与中和抗体复合物的结构：精氨酸-甘氨酸-天冬氨酸基序在相互作用中的直接参与
EMBO J. 1995 Apr 18;14(8):1690-6. doi: 10.1002/j.1460-2075.1995.tb07158.x.
8
Evolution of the capsid protein genes of foot-and-mouth disease virus: antigenic variation without accumulation of amino acid substitutions over six decades.口蹄疫病毒衣壳蛋白基因的演变：六十年来无氨基酸替换积累的抗原变异
J Virol. 1992 Jun;66(6):3557-65. doi: 10.1128/JVI.66.6.3557-3565.1992.