X射线影响5-碘脱氧尿苷掺入脱氧核糖核酸。
X-rays affect the incorporation of 5-iododeoxyuridine into deoxyribonucleic acid.
作者信息
GITLIN D, COMMERFORD S L, AMSTERDAM E, HUGHES W L
出版信息
Science. 1961 Apr 7;133(3458):1074-5. doi: 10.1126/science.133.3458.1074.
Abstract
When labeled with iodine-131, 5-iododeoxyuridine, an analogue of thymidine, is useful in estimating the effect of x-radiation on deoxyribonucleic acid metabolism. Although this compound is readily incorporated into deoxyribonucleic acid in the absence of ionizing radiation, we find that whole-body exposure to as little as 10 r will significantly inhibit its incorporation.
摘要
当用碘-131标记时，胸腺嘧啶核苷的类似物5-碘脱氧尿苷可用于评估X射线辐射对脱氧核糖核酸代谢的影响。虽然在没有电离辐射的情况下这种化合物很容易掺入脱氧核糖核酸中，但我们发现全身暴露于低至10伦琴的辐射下会显著抑制其掺入。
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