Liuzzi G M, Mastroianni C M, Vullo V, Jirillo E, Delia S, Riccio P
Dipartimento di Biochimica e Biologia Molecolare, Università di Bari, Italy.
J Neuroimmunol. 1992 Feb;36(2-3):251-4. doi: 10.1016/0165-5728(92)90058-s.
Myelin basic protein (MBP) was measured in cerebrospinal fluid (CSF) of patients with acquired immunodeficiency syndrome (AIDS) dementia complex (ADC) in order to investigate the degree of white matter destruction. Results show that increased CSF levels of MBP were detected in all patients with severe ADC (10/10) and, less often, in subjects with mild (2/7) or moderate dementia (7/16). No evidence of MBP-elevated concentration was observed in 14 human immunodeficiency virus (HIV)-seropositive subjects without neurological disorders and in nine HIV-seronegative controls. Our findings suggest that the measurement of CSF MBP concentration may represent a predictive marker of myelin injury and neurologic damage during the course of ADC.
为了研究白质破坏程度，对获得性免疫缺陷综合征（AIDS）痴呆综合征（ADC）患者的脑脊液（CSF）中的髓鞘碱性蛋白（MBP）进行了检测。结果显示，所有重度ADC患者（10/10）的脑脊液MBP水平均升高，轻度（2/7）或中度痴呆患者（7/16）中也有较少升高情况。在14名无神经系统疾病的人类免疫缺陷病毒（HIV）血清阳性受试者和9名HIV血清阴性对照中未观察到MBP浓度升高的证据。我们的研究结果表明，脑脊液MBP浓度的检测可能是ADC病程中髓鞘损伤和神经损伤的预测指标。
