• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Lack of cerebrospinal fluid myelin basic protein in HIV-infected asymptomatic individuals with intrathecal synthesis of IgG.

作者信息

Marshall D W, Brey R L, Butzin C A

机构信息

Department of Neurology, Wilford Hall USAF Medical Center, San Antonio, TX.

出版信息

Neurology. 1989 Aug;39(8):1127-9. doi: 10.1212/wnl.39.8.1127.

DOI:10.1212/wnl.39.8.1127
PMID:2474773
Abstract

We evaluated 130 consecutive HIV-infected neurologically asymptomatic individuals for intrathecal IgG production and myelin basic protein (MBP) levels. Although 56.7% of immunologically normal and 68.8% of immunocompromised patients had some CSF abnormality, no patient had an abnormal MBP level. The lack of MBP elevation in the CSF of these patients suggests that the production of intrathecal IgG is not related to active demyelination.

摘要

相似文献

1
Lack of cerebrospinal fluid myelin basic protein in HIV-infected asymptomatic individuals with intrathecal synthesis of IgG.
Neurology. 1989 Aug;39(8):1127-9. doi: 10.1212/wnl.39.8.1127.
2
Intrathecal synthesis of anti-myelin basic protein IgG in HIV-1+ patients.HIV-1阳性患者鞘内抗髓鞘碱性蛋白IgG的合成
Acta Neurol Scand. 1994 Oct;90(4):285-92. doi: 10.1111/j.1600-0404.1994.tb02723.x.
3
Myelin basic protein in the cerebrospinal fluid of patients infected with HIV.感染HIV患者脑脊液中的髓鞘碱性蛋白
J Neurol. 1989 Jul;236(5):288-91. doi: 10.1007/BF00314458.
4
Cerebrospinal fluid myelin basic protein as predictive marker of demyelination in AIDS dementia complex.脑脊液髓鞘碱性蛋白作为艾滋病痴呆综合征中脱髓鞘的预测标志物。
J Neuroimmunol. 1992 Feb;36(2-3):251-4. doi: 10.1016/0165-5728(92)90058-s.
5
CSF myelin basic protein, IgG and IgM levels in 101 MS patients before and after treatment with high-dose intravenous methylprednisolone.
Acta Neurol Scand. 1992 Sep;86(3):291-7. doi: 10.1111/j.1600-0404.1992.tb05088.x.
6
Intrathecal reactivity for myelin components precedes development of neurological symptoms in AIDS patients.艾滋病患者中，鞘内对髓鞘成分的反应性先于神经症状出现。
Arch Med Res. 1997 Autumn;28(3):391-6.
7
Association between intrathecal anti-HIV-1 immunoglobulin G synthesis and occurrence of HIV-1 in cerebrospinal fluid.鞘内抗HIV-1免疫球蛋白G合成与脑脊液中HIV-1出现之间的关联。
AIDS. 1989 Nov;3(11):701-5. doi: 10.1097/00002030-198911000-00003.
8
Cerebrospinal fluid levels of myelin basic protein and creatin kinase BB as index of active demyelination.脑脊液中髓鞘碱性蛋白和肌酸激酶BB水平作为活动性脱髓鞘的指标。
Acta Neurol Scand. 1986 Feb;73(2):203-7. doi: 10.1111/j.1600-0404.1986.tb03264.x.
9
Intrathecal humoral immunologic response in neurologically symptomatic and asymptomatic patients with human immunodeficiency virus infection.患有人类免疫缺陷病毒感染的有神经系统症状和无症状患者的鞘内体液免疫反应。
Neurology. 1988 Sep;38(9):1451-6. doi: 10.1212/wnl.38.9.1451.
10
Detection of antibodies against myelin basic protein and increased levels of HIV-IgG antibodies and HIV antigen after solubilization of immune complexes in sera and CSF of HIV infected patients.
Viral Immunol. 1989;2(1):1-9. doi: 10.1089/vim.1989.2.1.

引用本文的文献

1
Compartmentalized intrathecal immunoglobulin synthesis during HIV infection - a model of chronic CNS inflammation?HIV感染期间鞘内免疫球蛋白合成的区室化——慢性中枢神经系统炎症的一种模型？
J Neuroimmunol. 2015 Aug 15;285:41-52. doi: 10.1016/j.jneuroim.2015.05.015. Epub 2015 May 16.
2
Human immunodeficiency virus type 1 infection of the brain.1型人类免疫缺陷病毒脑部感染
Clin Microbiol Rev. 1993 Oct;6(4):339-66. doi: 10.1128/CMR.6.4.339.
3
Cerebrospinal fluid (CSF) analyses in HIV-1 primary neurological disease.HIV-1原发性神经系统疾病中的脑脊液（CSF）分析
Ital J Neurol Sci. 1992 Nov;13(8):667-83. doi: 10.1007/BF02334971.