青少年类风湿关节炎中CD5⁺ B细胞的增加。与IgM类风湿因子表达及疾病活动的关系。
Increase in CD5+ B cells in juvenile rheumatoid arthritis. Relationship to IgM rheumatoid factor expression and disease activity.
作者信息
Jarvis J N, Kaplan J, Fine N
机构信息
Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI.
出版信息
Arthritis Rheum. 1992 Feb;35(2):204-7. doi: 10.1002/art.1780350213.
OBJECTIVE
To investigate the association between CD5+ B cell expression and IgM rheumatoid factor (IgM-RF) in juvenile rheumatoid arthritis (JRA).
METHODS
CD5+ B cell levels analyzed by flow cytometry and IgM-RF expression determined by enzyme-linked immunosorbent assay were compared in children with JRA, children with other collagen vascular diseases, and healthy controls.
RESULTS
Children with polyarticular JRA had expanded populations of CD5+ B cells, and expansion of CD5+ B cells and IgM-RF both correlated with disease activity.
CONCLUSION
The results indicate that an expanded CD5+ B cell population leads to IgM-RF production in patients with polyarticular JRA, as well as patients with RA.
目的
研究青少年类风湿性关节炎（JRA）中CD5+B细胞表达与IgM类风湿因子（IgM-RF）之间的关联。
方法
对JRA患儿、其他胶原血管疾病患儿及健康对照者，比较通过流式细胞术分析的CD5+B细胞水平以及通过酶联免疫吸附测定法测定的IgM-RF表达。
结果
多关节型JRA患儿的CD5+B细胞群体增多，且CD5+B细胞增多和IgM-RF均与疾病活动相关。
结论
结果表明，多关节型JRA患者以及类风湿性关节炎（RA）患者中，CD5+B细胞群体增多会导致IgM-RF产生。
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