Yamamoto H, Yoshimura H, Noma M, Kai H, Suzuki S, Tajimi T, Sugihara M, Kikuchi Y
Department of Medicine, Kyushu Welfare Pension Hospital, Fukuoka, Japan.
Am Heart J. 1992 Feb;123(2):298-303. doi: 10.1016/0002-8703(92)90638-c.
The objective of this study was to determine if endothelium-dependent vasodilation is preserved in the spastic segment of the epicardial coronary artery. Segmental responses of the coronary artery to substance P were examined by the use of a quantitative angiographic technique in 21 patients with variant angina. Coronary diameter at the basal state did not differ between the spastic and the nonspastic segments (2.3 +/- 0.2 mm, 2.3 +/- 0.4 mm, p greater than 0.05). Changes in coronary diameter in response to substance P did not differ between segments with ergonovine-induced spasm and nonspastic segments. Maximal dilation averaged 27.1 +/- 9.5% in the spastic segment and 24.4 +/- 9.6% in the nonspastic segment (expressed as a percent increase over the value before drug administration). It appears that both the potential of the endothelium to release endothelium-dependent relaxing factor and the dilating response of the smooth muscle to endothelium-dependent relaxing factor are preserved, even in the spastic segment.
本研究的目的是确定心外膜冠状动脉痉挛段的内皮依赖性血管舒张功能是否得以保留。采用定量血管造影技术，对21例变异型心绞痛患者冠状动脉对P物质的节段性反应进行了研究。痉挛段和非痉挛段的基础状态下冠状动脉直径无差异（2.3±0.2mm，2.3±0.4mm，p＞0.05）。麦角新碱诱发痉挛的节段与非痉挛节段对P物质反应的冠状动脉直径变化无差异。痉挛段最大扩张平均为27.1±9.5%，非痉挛段为24.4±9.6%（以给药前值的百分比增加表示）。即使在痉挛段，内皮释放内皮依赖性舒张因子的能力和平滑肌对内皮依赖性舒张因子的舒张反应似乎均得以保留。
