肾上腺素、去甲肾上腺素和异丙肾上腺素对豚鼠子宫的作用。
The effect of adrenaline, noradrenaline and isoprenaline on the guinea-pig uterus.
作者信息
HERMANSEN K
出版信息
Br J Pharmacol Chemother. 1961 Feb;16(1):116-28. doi: 10.1111/j.1476-5381.1961.tb00304.x.
The actions of adrenaline, noradrenaline and isoprenaline were compared on the isolated guinea-pig uterus. In uteri from immature animals (200 to 350 g) adrenaline caused relaxation which changed to a biphasic effect and finally to a contraction in the course of an experiment (6 to 8 hr). Noradrenaline always caused contraction and isoprenaline relaxation. In uteri from oestrogen-treated animals adrenaline and noradrenaline caused contraction and isoprenaline caused relaxation. Isoprenaline potentiated the contraction produced by adrenaline and reversed the adrenaline relaxation to a contraction. The change of the pharmacological action of adrenaline was not related to the Na(+) and K(+) content of the uterus, which remained constant throughout an experiment involving repeated application of the amines. Nor could it be related to a change in the glycogenolytic effect of adrenaline estimated by determinations of total glycogen of the muscle which, however, may not reflect a momentary change in rate of breakdown.
对豚鼠离体子宫比较了肾上腺素、去甲肾上腺素和异丙肾上腺素的作用。在未成熟动物（200至350克）的子宫中，肾上腺素引起松弛，在实验过程中（6至8小时）这种松弛转变为双相效应，最终转变为收缩。去甲肾上腺素始终引起收缩，而异丙肾上腺素引起松弛。在雌激素处理过的动物的子宫中，肾上腺素和去甲肾上腺素引起收缩，而异丙肾上腺素引起松弛。异丙肾上腺素增强了肾上腺素产生的收缩，并将肾上腺素引起的松弛转变为收缩。肾上腺素药理作用的变化与子宫中钠（+）和钾（+）的含量无关，在涉及重复应用胺类的整个实验过程中，子宫中钠（+）和钾（+）的含量保持恒定。它也与通过测定肌肉总糖原估计的肾上腺素糖原分解作用的变化无关，然而，这可能无法反映分解速率的瞬间变化。
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