Isoyama K, Baliga S, Shah A, Mankad V N
University of South Alabama Comprehensive Sickle Cell Center, Mobile.
Am J Hematol. 1992 Jan;39(1):65-6. doi: 10.1002/ajh.2830390115.
DNA-synthesis state of circulating burst forming unit-erythroid (BFU-E) was evaluated in patients with sickle cell anemia and correlated with percent of fetal hemoglobin synthesized in the BFU-E-derived cells. Percentage of S-phase BFU-E inversely correlated with percent fetal hemoglobin synthesized in the BFU-E-derived cells (simple linear correlation coefficient, r = -0.8, P = 0.0302; polynomial regression, R = -0.99, P = 0.0002). This observation is of relevance to our understanding of the relationship between the developmental stage of the erythroid progenitors and expression of globin genes.
