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1
The effects of acetylcholine on the turnover of phosphatidic acid and phosphoinositide in sympathetic ganglia, and in various parts of the central nervous system in vitro.乙酰胆碱对交感神经节以及体外中枢神经系统各部位中磷脂酸和磷酸肌醇周转的影响。
J Gen Physiol. 1960 Nov;44(2):217-26. doi: 10.1085/jgp.44.2.217.
2
Studies on the carrier function of phosphatidic acid in sodium transport. I. The turnover of phosphatidic acid and phosphoinositide in the avian salt gland on stimulation of secretion.磷脂酸在钠转运中的载体功能研究。I. 刺激分泌时禽盐腺中磷脂酸和磷酸肌醇的周转。
J Gen Physiol. 1960 Sep;44(1):61-85. doi: 10.1085/jgp.44.1.61.
3
The role of phosphatidic acid and phosphoinositide in transmembrane transport elicited by acetylcholine and other humoral agents.磷脂酸和磷酸肌醇在乙酰胆碱及其他体液因子引发的跨膜转运中的作用。
Int Rev Neurobiol. 1960;2:99-136. doi: 10.1016/s0074-7742(08)60121-x.
4
Choline and phospholipid-choline in a sympathetic ganglion and their relationship to acetylcholine synthesis.交感神经节中的胆碱和磷脂胆碱及其与乙酰胆碱合成的关系。
Nature. 1967 May 13;214(5089):722-4. doi: 10.1038/214722a0.
5
Muscarinic cholinergic stimulation of phosphatidylinositol turnover in isolated rat superior cervical sympathetic ganglia.毒蕈碱胆碱能刺激对离体大鼠颈上神经节中磷脂酰肌醇周转的影响
J Neurochem. 1976 Mar;26(3):649-51. doi: 10.1111/j.1471-4159.1976.tb01530.x.
6
The influence of neural activity on neural metabolism of glucose and phospholipid.神经活动对神经葡萄糖和磷脂代谢的影响。
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Effects of acetylcholine on the incorporation of 32P into various phospholipids in sices of normal and denervated superior cervical ganglia of the cat.乙酰胆碱对猫正常和去神经支配的颈上神经节切片中32P掺入各种磷脂的影响。
J Neurochem. 1966 Mar;13(3):179-84. doi: 10.1111/j.1471-4159.1966.tb07511.x.
8
Autoradiographic localization of the acetylcholine-stimulated synthesis of phosphatidylinositol in the superior cervical ganglion.乙酰胆碱刺激颈上神经节中磷脂酰肌醇合成的放射自显影定位。
Proc Natl Acad Sci U S A. 1965 Jun;53(6):1369-76. doi: 10.1073/pnas.53.6.1369.
9
Acetylcholine stimulates hydrolysis of 32 P-labeled phosphatidic acid in guinea pig synaptosomes.乙酰胆碱刺激豚鼠突触小体中32P标记的磷脂酸的水解。
Biochem Biophys Res Commun. 1973 Feb 5;50(3):934-41. doi: 10.1016/0006-291x(73)91335-1.
10
The influence of temperature on the acetylcholine output from a sympathetic ganglion.温度对交感神经节乙酰胆碱释放量的影响。
J Physiol. 1956 Apr 27;132(1):239-41. doi: 10.1113/jphysiol.1956.sp005518.

引用本文的文献

1
Phosphoinositides: Regulators of Nervous System Function in Health and Disease.磷酸肌醇：健康与疾病中神经系统功能的调节因子
Front Mol Neurosci. 2019 Aug 23;12:208. doi: 10.3389/fnmol.2019.00208. eCollection 2019.
2
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Rapid accumulation of inositol phosphates in isolated rat superior cervical sympathetic ganglia exposed to V1-vasopressin and muscarinic cholinergic stimuli.在暴露于V1-血管加压素和毒蕈碱胆碱能刺激的离体大鼠颈上神经节中，肌醇磷酸迅速积累。
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Factors affecting incorporation of precursors into body constituents: a review of common sense considerations with glycolipids as examples.影响前体掺入身体成分的因素：以糖脂为例的常识性考量综述
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5
Stimulation by acetylcholine of phosphatidylinositol labelling. Subcellular distribution in rat cerebral-cortex slices.乙酰胆碱对磷脂酰肌醇标记的刺激作用。大鼠大脑皮层切片中的亚细胞分布。
Biochem J. 1972 Mar;126(5):1141-7. doi: 10.1042/bj1261141.
6
Autoradiographic localization of the acetylcholine-stimulated synthesis of phosphatidylinositol in the superior cervical ganglion.乙酰胆碱刺激颈上神经节中磷脂酰肌醇合成的放射自显影定位。
Proc Natl Acad Sci U S A. 1965 Jun;53(6):1369-76. doi: 10.1073/pnas.53.6.1369.
7
Histochemical observation of bovine spinal ganglia.牛脊髓神经节的组织化学观察。
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8
Accumulation of inositol phosphates in sympathetic ganglia. Effects of depolarization and of amine and peptide neurotransmitters.交感神经节中肌醇磷酸的积累。去极化以及胺类和肽类神经递质的作用。
Biochem J. 1985 Apr 1;227(1):263-9. doi: 10.1042/bj2270263.

本文引用的文献

1
The immediate and delayed effects of diisopropylfluorophosphate injected into the supraoptic nuclei of dogs.向狗的视上核注射二异丙基氟磷酸酯的即时和延迟效应。
J Physiol. 1950 Apr 15;111(1-2):81-8. doi: 10.1113/jphysiol.1950.sp004465.
2
The action of acetylcholine in the supraoptic nucleus of the chloralosed dog.水合氯醛麻醉犬视上核中乙酰胆碱的作用。
J Physiol. 1947 Jul 31;106(3):264-70. doi: 10.1113/jphysiol.1947.sp004209.
3
An improved method for the colorimetric determination of phosphate.一种改进的比色法测定磷酸盐的方法。
Biochem J. 1938 Feb;32(2):295-8. doi: 10.1042/bj0320295.
4
Evidence for phosphatidic acid as the sodium carrier.磷脂酸作为钠载体的证据。
Nature. 1959 Oct 3;184(Suppl 14):1068-9. doi: 10.1038/1841068a0.
5
The role of phosphatidic acid and phosphoinositide in transmembrane transport elicited by acetylcholine and other humoral agents.磷脂酸和磷酸肌醇在乙酰胆碱及其他体液因子引发的跨膜转运中的作用。
Int Rev Neurobiol. 1960;2:99-136. doi: 10.1016/s0074-7742(08)60121-x.
6
The mechanism of phosphate exchange in phosphatidic acid in response to acetylcholine.磷脂酸中磷酸盐交换对乙酰胆碱作出反应的机制。
J Biol Chem. 1959 Jun;234(6):1387-90.
7
The synthesis of phosphatidic acid from diglyceride and adenosine triphosphate in extracts of brain microsomes.在脑微粒体提取物中由甘油二酯和三磷酸腺苷合成磷脂酸。
J Biol Chem. 1959 Jun;234(6):1381-6.
8
Acetylcholine and the exchange of phosphate in phosphatidic acid in brain microsomes.乙酰胆碱与脑微粒体中磷脂酸的磷酸交换
J Biol Chem. 1958 Oct;233(4):822-6.
9
Acetylcholine and the exchange of inositol and phosphate in brain phosphoinositide.乙酰胆碱与脑磷酸肌醇中肌醇和磷酸的交换
J Biol Chem. 1958 Oct;233(4):818-21.
10
Phospholipides and adrenaline secretion in guinea pig adrenal medulla.豚鼠肾上腺髓质中的磷脂与肾上腺素分泌
J Biol Chem. 1958 Oct;233(4):814-7.

乙酰胆碱对交感神经节以及体外中枢神经系统各部位中磷脂酸和磷酸肌醇周转的影响。

The effects of acetylcholine on the turnover of phosphatidic acid and phosphoinositide in sympathetic ganglia, and in various parts of the central nervous system in vitro.

作者信息

HOKIN M R, HOKIN L E, SHELP W D

出版信息

J Gen Physiol. 1960 Nov;44(2):217-26. doi: 10.1085/jgp.44.2.217.

DOI:10.1085/jgp.44.2.217
PMID:13715211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2195095/
Abstract

The effect of acetylcholine on the incorporation of P(32) into the individual phosphatides in slices of various structures of the nervous system has been studied. There was a marked stimulation of P(32) incorporation into phosphoinositide and phosphatidic acid, but not into phosphatidyl choline and phosphatidyl ethanolamine, in the cat stellate and celiac ganglia in vitro. Acetylcholine stimulated P(32) incorporation into certain phosphatides, primarily phosphoinositide and phosphatidic acid, in several structures of the cat and guinea pig brain; there was little or no effect of acetylcholine on phosphatide turnover in the inferior corpora quadrigsemina and cerebellar cortex. The suggestion is made that the phospholipid effect can best be explained as being concerned with the active transport of sodium ions out of the cell across the postsynaptic membrane of cholinergic neurons in response to acetylcholine.

摘要

已经研究了乙酰胆碱对神经系统不同结构切片中P(32)掺入各个磷脂的影响。在体外猫星状神经节和腹腔神经节中，P(32)掺入磷酸肌醇和磷脂酸有明显的刺激作用，但对磷脂酰胆碱和磷脂酰乙醇胺则无此作用。乙酰胆碱刺激猫和豚鼠脑的几种结构中P(32)掺入某些磷脂，主要是磷酸肌醇和磷脂酸；乙酰胆碱对下四叠体和小脑皮质的磷脂周转几乎没有影响。有人提出，磷脂效应最好解释为与乙酰胆碱作用下钠离子通过胆碱能神经元突触后膜从细胞内的主动转运有关。