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上皮细胞转运在 ……

Epithelial transport in .

机构信息

Department of Physiology and Biophysics, Weill-Cornell Medical College, New York, NY

出版信息

J Gen Physiol. 2017 Oct 2;149(10):897-909. doi: 10.1085/jgp.201711828. Epub 2017 Sep 20.

DOI:10.1085/jgp.201711828
PMID:28931633
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5688356/
Abstract

Epithelia define the boundaries of the body and often transfer solutes and water from outside to inside (absorption) or from inside to outside (secretion). Those processes involve dual plasma membranes with different transport components that interact with each other. Understanding those functions has entailed breaking down the problem to analyze properties of individual membranes (apical vs. basolateral) and individual transport proteins. It also requires understanding of how those components interact and how they are regulated. This article outlines the modern history of this research as reflected by publications in .

摘要

上皮细胞界定了身体的边界，通常将溶质和水从外部转移到内部（吸收）或从内部转移到外部（分泌）。这些过程涉及具有不同转运成分的双层质膜，它们相互作用。理解这些功能需要将问题分解为分析单个膜（顶侧与基底外侧）和单个转运蛋白的性质。它还需要了解这些成分如何相互作用以及如何进行调节。本文概述了这方面的现代研究历史，这反映在《 》杂志的出版物中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ce6/5688356/ba85d5b5d433/JGP_201711828_Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ce6/5688356/3725122f40ac/JGP_201711828_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ce6/5688356/9e0a25c32034/JGP_201711828_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ce6/5688356/9019203a012b/JGP_201711828_Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ce6/5688356/06b8255d523e/JGP_201711828_Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ce6/5688356/337486237f1a/JGP_201711828_Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ce6/5688356/ba85d5b5d433/JGP_201711828_Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ce6/5688356/3725122f40ac/JGP_201711828_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ce6/5688356/9e0a25c32034/JGP_201711828_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ce6/5688356/9019203a012b/JGP_201711828_Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ce6/5688356/06b8255d523e/JGP_201711828_Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ce6/5688356/337486237f1a/JGP_201711828_Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ce6/5688356/ba85d5b5d433/JGP_201711828_Fig6.jpg

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引用本文的文献

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本文引用的文献

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Activation of the Ano1 (TMEM16A) chloride channel by calcium is not mediated by calmodulin.钙激活的 Ano1（TMEM16A）氯离子通道不是由钙调蛋白介导的。
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