Jones S J
National Hospital for Neurology and Neurosurgery, London, U.K.
Electroencephalogr Clin Neurophysiol. 1992 Mar-Apr;84(2):149-56. doi: 10.1016/0168-5597(92)90019-8.
Long latency auditory evoked potentials (AEPs), chiefly consisting of a negative peak at about 150 msec and a positivity at 250 msec, were recorded at the beginning and end of periods during which the interaural time difference of binaural noise was switched between 0.0 and 0.8 msec at a fast rate (ISI = 50 or 25 msec) or the frequency of continuous binaural clicks was switched between 167 and 200 Hz every 80, 50 or 25 msec. In the latter case the offset responses occurred later than onset by a mean of 89, 47 and 27 msec respectively, suggesting they were probably generated at the moment the next switch was expected but failed to occur. The offset responses must be non-specific with respect to the interaural delay or the frequency of clicks, since neurones which respond to particular delays or frequencies and are made refractory by a rapid rate of stimulation should not suddenly become less so at the last in a series of identical stimuli, or be activated by the absence of a further event. It is proposed that the potentials are due to a higher order of neurone which automatically responds to the occurrence of a "mismatch" between the immediate sound and an image of that which was previously present, encoded in a short-term sensory store. In addition to frequency content and interaural delay, the image must contain information about the temporal modulation pattern of the sound over the previous few seconds.
长潜伏期听觉诱发电位（AEPs）主要由大约150毫秒处的一个负峰和250毫秒处的一个正峰组成，在双耳噪声的双耳时间差以快速率（ISI = 50或25毫秒）在0.0和0.8毫秒之间切换，或者连续双耳咔哒声的频率每80、50或25毫秒在167和200赫兹之间切换的时间段的开始和结束时进行记录。在后一种情况下，偏移反应分别比起始反应延迟89、47和27毫秒出现，这表明它们可能是在预期下一次切换但未发生时产生的。偏移反应对于双耳延迟或咔哒声频率一定是非特异性的，因为对特定延迟或频率有反应且因快速刺激速率而变得不应期的神经元，在一系列相同刺激中的最后一个刺激时，不应突然变得不那么不应期，也不应因没有进一步的事件而被激活。有人提出，这些电位是由于一种更高阶的神经元引起的，这种神经元会自动对即时声音与先前存在的声音图像之间的“不匹配”的出现做出反应，该图像编码在短期感觉存储中。除了频率内容和双耳延迟外，该图像还必须包含关于前几秒声音的时间调制模式的信息。
