Motojima K, Tomioka T, Kohara N, Tsunoda T, Kanematsu T
Second Department of Surgery, University of Nagasaki School of Medicine, Japan.
J Surg Oncol. 1992 Jan;49(1):58-62. doi: 10.1002/jso.2930490114.
Six patients with adenosquamous carcinoma (ASqC) of the pancreas were studied clinicopathologically and immunohistochemically. In five of six ASqC tumors, both malignant squamous and glandular elements were reactive with CA 19-9, ST 439, and keratin antibodies. In contrast, a portion of the glandular element in the remaining one ASqC was reactive with CA 19-9 and ST 439 antibodies, but that of the squamous cell carcinoma (SqCC) was not reactive. However, SqCC of this tumor was intensely reactive with keratin antibody. These immunohistochemical results suggest that the histogenesis in one ASqC tumor was different from that of the other 5 ASqCs, and that this tumor may be a collision tumor rather than transformation to SqCC from adenocarcinoma, which is a very rare pattern of histogenesis in ASqC. The patients with ASqC of the pancreas showed shorter survivals following operations because of systemic metastasis including liver metastasis.
对6例胰腺腺鳞癌（ASqC）患者进行了临床病理和免疫组化研究。在6例ASqC肿瘤中的5例中，恶性鳞状和腺性成分均与CA 19-9、ST 439和角蛋白抗体呈反应性。相比之下，其余1例ASqC中部分腺性成分与CA 19-9和ST 439抗体呈反应性，但鳞状细胞癌（SqCC）成分无反应性。然而，该肿瘤的SqCC与角蛋白抗体呈强反应性。这些免疫组化结果表明，1例ASqC肿瘤的组织发生与其他5例不同，且该肿瘤可能是碰撞瘤，而非腺癌向SqCC的转化，这在ASqC中是一种非常罕见的组织发生模式。胰腺ASqC患者术后因包括肝转移在内的全身转移而生存期较短。
