Schneider J, Efferth T, Mattern J, Rodriguez-Escudero F J, Volm M
University of the Basque Country, Hospital de Cruces, Bilbao, Spain.
Am J Obstet Gynecol. 1992 Mar;166(3):825-9. doi: 10.1016/0002-9378(92)91341-7.
Uterine cervical carcinomas and normal cervical tissue (controls) were investigated for the presence of the multi-drug-resistance gene product P-glycoprotein by means of immunohistochemistry, with the C219 monoclonal antibody and the streptavidin-biotin-peroxidase technique. Ten of 11 cervical carcinomas, 2 of which were previously treated with chemotherapeutic agents of the multi-drug-resistance group, showed a positive reaction of tumor cells. All normal controls showed a positive reaction of the ectocervical and endocervical epithelial cells. P-glycoprotein seems to be implicated at least in part in resistance to chemotherapy of cervical carcinoma.
