Samid D, Shack S, Sherman L T
Clinical Pharmacology Branch, National Cancer Institute, Bethesda, Maryland 20892.
Cancer Res. 1992 Apr 1;52(7):1988-92.
Sodium phenylacetate was found to affect the growth and differentiation of tumor cells in vitro at concentrations that have been achieved in humans with no significant adverse effects. Treatment of promyelocytic leukemia HL-60 cells resulted in the rapid decline of myc oncogene expression followed by growth arrest and granulocyte differentiation. Phenylacetate also induced highly efficient adipocyte conversion in immortalized mesenchymal C3H 10T1/2 cultures; yet, unlike the differentiating chemotherapeutic drug 5-aza-2'-deoxycytidine, phenylacetate did not cause neoplastic transformation in these susceptible cells. The results indicate that phenylacetate is both effective in inducing tumor cell maturation and free of cytotoxic and carcinogenic effects, a combination that warrants attention to its potential use in cancer intervention.
已发现苯乙酸钠在人体所能达到的浓度下可影响肿瘤细胞的生长和分化，且无明显不良反应。用其处理早幼粒细胞白血病HL - 60细胞会导致myc癌基因表达迅速下降，随后细胞生长停滞并向粒细胞分化。苯乙酸还能在永生化间充质C3H 10T1/2培养物中高效诱导脂肪细胞转化；然而，与分化型化疗药物5 - 氮杂-2'-脱氧胞苷不同，苯乙酸在这些敏感细胞中不会引起肿瘤转化。结果表明，苯乙酸在诱导肿瘤细胞成熟方面有效，且无细胞毒性和致癌作用，这种特性值得关注其在癌症干预中的潜在用途。
