EINSTEIN H E, HOLEMAN C W, SANDIDGE L L, HOLDEN D H
Calif Med. 1961 Jun;94(6):339-43.
Amphotericin B is the first agent to alter favorably the course of coccidioidal meningitis. The morbidity and toxicity of the drug are at present its chief limiting factors. Although no cures were obtained in a series of 11 cases, significant remissions usually followed a course of therapy. Comparison with similar groups showed a significant prolongation of life in adequately treated cases.
两性霉素B是第一种能有效改变球孢子菌性脑膜炎病程的药物。该药的发病率和毒性是目前其主要的限制因素。虽然在11例患者的系列治疗中未取得治愈效果，但经过一个疗程的治疗后通常会有显著缓解。与相似组别的比较表明，接受充分治疗的病例生存期显著延长。
