Golomb J, Lindner A, Siegel Y, Korczak D
Department of Urology, Edith Wolfson Medical Center, Holon, Israel.
J Urol. 1992 Apr;147(4):1044-7. doi: 10.1016/s0022-5347(17)37462-1.
We evaluated the variability and circadian changes in consecutive measurements of home uroflowmetry in 32 patients with symptomatic benign prostatic hyperplasia (BPH) and 16 healthy men. In the BPH group 476 uroflow measurements were recorded during 24 to 72 hours (mean 14.9 measurements per patient), and the controls produced 100 flow recordings (mean 6.25 measurements per participant). Great variability between consecutive peak flow rates was observed in the BPH group, ranging from at least 1 standard deviation in 28 of 32 patients (87.5%) to at least 2 standard deviations in 15 of 32 (47%). In 21 of 32 patients (65.6%) the highest recorded peak flow rate was greater than, while the lowest peak flow rate was less than the -2 standard deviations plot in voiding nomograms. In the control group variability between consecutive voiding episodes also was marked, namely at least 1 standard deviation in 8 of 16 men (50.0%) and at least 2 standard deviations in 2 of 16 (12.5%). However, in none of the control men was any peak flow rate measurement less than the -2 standard deviations line. Circadian changes in diurnal and nocturnal measurements of voided volume, interval to maximal flow, flow time, peak flow rate and adjusted peak flow rate were recorded in the BPH group, providing a urodynamic support to a well known clinical observation.
我们评估了32例有症状的良性前列腺增生（BPH）患者和16名健康男性连续进行家庭尿流率测定的变异性和昼夜变化。在BPH组中，在24至72小时内记录了476次尿流率测量值（平均每位患者14.9次测量），对照组进行了100次尿流记录（平均每位参与者6.25次测量）。在BPH组中观察到连续峰值尿流率之间存在很大变异性，32例患者中有28例（87.5%）至少相差1个标准差，32例中有15例（47%）至少相差2个标准差。在32例患者中的21例（65.6%）中，记录到的最高峰值尿流率大于排尿列线图中-2标准差线，而最低峰值尿流率小于该线。在对照组中，连续排尿事件之间的变异性也很明显，16名男性中有8名（50.0%）至少相差1个标准差，16名中有2名（12.5%）至少相差2个标准差。然而，对照组中没有一名男性的任何峰值尿流率测量值低于-2标准差线。在BPH组中记录了日间和夜间排尿量、达到最大尿流时间间隔、尿流时间、峰值尿流率和调整后峰值尿流率的昼夜变化，为一项众所周知的临床观察提供了尿动力学支持。
