不同染色体来源的小嵌合标记物的产前鉴定。
Prenatal identification of small mosaic markers of different chromosomal origins.
作者信息
Stetten G, Blakemore K J, Courter A M, Coss C A, Jabs E W
机构信息
Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD.
出版信息
Prenat Diagn. 1992 Feb;12(2):83-91. doi: 10.1002/pd.1970120203.
In situ hybridization using a series of alphoid DNA probes has demonstrated the origin of two small accessory mosaic marker chromosomes ascertained from 1079 amniocenteses. These markers appeared to be de novo, derived from acrocentric chromosomes, and identical by traditional cytogenetic staining (G, Q, C, AgNOR, Hoechst-distamycin). Molecular characterization showed that one marker had originated from chromosome 14, the other from chromosome 22. Clinical outcome in both cases was normal.
使用一系列α卫星DNA探针进行的原位杂交已证实了从1079例羊膜穿刺术中确定的两条小的附加嵌合标记染色体的起源。这些标记似乎是从头产生的，源自近端着丝粒染色体，并且通过传统细胞遗传学染色（G、Q、C、AgNOR、Hoechst-地霉素）显示相同。分子特征表明，一个标记源自14号染色体，另一个源自22号染色体。两例的临床结局均正常。
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