De Santo N G, Capasso G, Anastasio P, Coppola S, Bellini L, Lombardi A
Department of Pediatrics, Università Federico II, Naples, Italy.
Ren Physiol Biochem. 1992 Jan-Feb;15(1):53-6. doi: 10.1159/000173441.
With the aim of disclosing a possibility for gastrin and bombesin to participate in the postprandial regulation of the renal hemodynamic response, 10 healthy males were studied before and after a meat meal (2 g/kg BW of proteins as cooked red meat). We evaluated the time course changes of glomerular filtration rate (GFR) renal plasma flow (RPF), and the plasma concentrations of gastrin, bombesin, glucagon, and total amino acids. After the meat meal a significant increase in GFR and RPF was seen, within 30 min, along with an increase in plasma gastrin and glucagon. Bombesin and amino acid concentrations increased at a later time. The data suggest but cannot demonstrate a causal role for gastrin and glucagon in the genesis of the hyperfiltration response to acute protein administration.
为了揭示胃泌素和蛙皮素参与餐后肾脏血流动力学反应调节的可能性，我们对10名健康男性在进食一顿肉餐（2克/千克体重的熟红肉蛋白质）前后进行了研究。我们评估了肾小球滤过率（GFR）、肾血浆流量（RPF）以及胃泌素、蛙皮素、胰高血糖素和总氨基酸的血浆浓度随时间的变化。肉餐后，30分钟内GFR和RPF显著增加，同时血浆胃泌素和胰高血糖素也增加。蛙皮素和氨基酸浓度在稍后时间增加。这些数据表明，但不能证明胃泌素和胰高血糖素在急性蛋白质摄入引起的超滤反应发生过程中起因果作用。
