与费城染色体相关的骨髓纤维化
Marrow fibrosis associated with a Philadelphia chromosome.
作者信息
Nowell P C, Kant J A, Finan J B, Cassileth P A, Hanson C A
机构信息
Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia 19104-6082.
出版信息
Cancer Genet Cytogenet. 1992 Mar;59(1):89-92. doi: 10.1016/0165-4608(92)90167-7.
PMID:1372840
Abstract
Three patients had marked marrow fibrosis and an apparent Philadelphia (Ph) chromosome. Hematologic, cytogenetic, and molecular studies demonstrated the heterogeneity of such cases, including the first example of clinically typical myelofibrosis (MF) associated with a bcr gene rearrangement characteristic of chronic myelogenous leukemia (CML).
摘要
三名患者存在明显的骨髓纤维化及可见的费城（Ph）染色体。血液学、细胞遗传学及分子学研究表明了此类病例的异质性，其中包括首例与慢性粒细胞白血病（CML）特征性bcr基因重排相关的临床典型骨髓纤维化（MF）。
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