Segawa Y, Ohnoshi T, Ueoka H, Kiura K, Horiguchi T, Kodani T, Kamei H, Tabata M, Shibayama T, Maeda T
Second Dept. of Internal Medicine, Dept. of Radiology, Okayama University Medical School, Japan.
Gan To Kagaku Ryoho. 1992 Apr;19(4):529-32.
A case of a 69-year-old man with locally advanced esophageal cancer was reported. The patient received five courses of chemotherapy consisting of cisplatin (30 mg i.v. days 1-5), 5-fluorouracil (500 mg i.v. days 1-5) and bleomycin (5 mg i.m. days 1-5) every four weeks with a split course irradiation at a dose of 50 Gy, which was concurrently given at the second, third and fourth course of the chemotherapy. Treatment was effectively carried out without severe toxicities. The patient achieved a histologically-confirmed complete remission after completion of the treatment. The patient is disease-free and fully active 28 months after the beginning of chemotherapy. The treatment modality appears to be useful for advanced esophageal cancer.
报告了一例69岁局部晚期食管癌男性患者。患者每四周接受五个疗程的化疗，化疗方案为顺铂（静脉注射30mg，第1 - 5天）、5-氟尿嘧啶（静脉注射500mg，第1 - 5天）和博来霉素（肌肉注射5mg，第1 - 5天），同时进行分割放疗，剂量为50Gy，在化疗的第二、第三和第四疗程同步进行。治疗有效实施，未出现严重毒性反应。治疗完成后，患者实现了组织学确诊的完全缓解。化疗开始28个月后，患者无疾病且活动自如。这种治疗方式似乎对晚期食管癌有效。
