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[1例局部晚期食管癌同步放化疗疗效显著]

[A case of locally advanced esophageal cancer effectively treated with concurrent chemotherapy and radiotherapy].

作者信息

Segawa Y, Ohnoshi T, Ueoka H, Kiura K, Horiguchi T, Kodani T, Kamei H, Tabata M, Shibayama T, Maeda T

机构信息

Second Dept. of Internal Medicine, Dept. of Radiology, Okayama University Medical School, Japan.

出版信息

Gan To Kagaku Ryoho. 1992 Apr;19(4):529-32.

PMID:1373050
Abstract

A case of a 69-year-old man with locally advanced esophageal cancer was reported. The patient received five courses of chemotherapy consisting of cisplatin (30 mg i.v. days 1-5), 5-fluorouracil (500 mg i.v. days 1-5) and bleomycin (5 mg i.m. days 1-5) every four weeks with a split course irradiation at a dose of 50 Gy, which was concurrently given at the second, third and fourth course of the chemotherapy. Treatment was effectively carried out without severe toxicities. The patient achieved a histologically-confirmed complete remission after completion of the treatment. The patient is disease-free and fully active 28 months after the beginning of chemotherapy. The treatment modality appears to be useful for advanced esophageal cancer.

摘要

报告了一例69岁局部晚期食管癌男性患者。患者每四周接受五个疗程的化疗,化疗方案为顺铂(静脉注射30mg,第1 - 5天)、5-氟尿嘧啶(静脉注射500mg,第1 - 5天)和博来霉素(肌肉注射5mg,第1 - 5天),同时进行分割放疗,剂量为50Gy,在化疗的第二、第三和第四疗程同步进行。治疗有效实施,未出现严重毒性反应。治疗完成后,患者实现了组织学确诊的完全缓解。化疗开始28个月后,患者无疾病且活动自如。这种治疗方式似乎对晚期食管癌有效。

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