Stenman G, Kindblom L G, Angervall L
Department of Oral Pathology, University of Göteborg, Sweden.
Genes Chromosomes Cancer. 1992 Mar;4(2):122-7. doi: 10.1002/gcc.2870040204.
Clear-cell sarcoma is a rare soft tissue sarcoma that displays certain similarities to malignant melanoma. In this paper we describe the karyotypic findings and in vitro growth characteristics of a short-term-cultured clear-cell sarcoma. The cultured tumor cells had preserved immunohistochemical characteristics and certain ultrastructural features of the primary tumour, including positivity for vimentin, S-100 protein, and a melanoma-associated antigen, supporting the authenticity of the cultured cells. Cytogenetic analysis revealed an abnormal stemline karyotype of 49,XY, -1, +8, +8, +12, +der(1)t(1;?)(p36.1-.3;?), t(12;22)(q13;q13). A similar or identical t(12;22) was recently reported in two of four clear-cell sarcomas. It is suggested that the t(12;22)(q13;q13) is a primary cytogenetic abnormality in clear-cell sarcoma and distinguishes this tumor type from malignant melanoma.
透明细胞肉瘤是一种罕见的软组织肉瘤，与恶性黑色素瘤有某些相似之处。在本文中，我们描述了一株短期培养的透明细胞肉瘤的核型分析结果及体外生长特性。培养的肿瘤细胞保留了原发肿瘤的免疫组化特征和某些超微结构特征，包括波形蛋白、S-100蛋白及一种黑色素瘤相关抗原呈阳性，这支持了培养细胞的真实性。细胞遗传学分析显示异常的干系核型为49,XY, -1, +8, +8, +12, +der(1)t(1;?)(p36.1-.3;?), t(12;22)(q13;q13)。最近在4例透明细胞肉瘤中的2例中报告了类似或相同的t(12;22)。提示t(12;22)(q13;q13)是透明细胞肉瘤的原发性细胞遗传学异常，可将该肿瘤类型与恶性黑色素瘤区分开来。
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