Pegelow C H
Department of Pediatrics, University of Miami School of Medicine, FL 33101.
Clin Pediatr (Phila). 1992 Apr;31(4):211-4. doi: 10.1177/000992289203100404.
A questionnaire was sent to principal investigators of NIH-sponsored clinical research in sickle cell disease. Twenty of 21 respondents indicated they used parenteral narcotic analgesics for pain episodes sufficiently severe to warrant hospitalization. Eleven used meperidine; seven, morphine; and one each, nalbuphine, hydromorphone, and acetaminophen with codeine. They gave the agents at frequent, regular intervals or by continuous infusion. A total of 41 of more than 3,500 patients required chronic transfusion for pain control. Complications included meperidine-associated convulsions reported by nine respondents and addiction by six. This information indicates that vigorous pain-control methods are used at institutions having a special interest in providing medical care for children with sickle cell disease.
一份调查问卷被发送给了国立卫生研究院资助的镰状细胞病临床研究的主要研究者。21名受访者中有20人表示，他们会对严重到需要住院治疗的疼痛发作使用胃肠外麻醉性镇痛药。11人使用度冷丁；7人使用吗啡；1人分别使用纳布啡、氢吗啡酮和对乙酰氨基酚加可待因。他们频繁、定期给药或持续输注这些药物。在3500多名患者中，共有41人需要长期输血以控制疼痛。并发症包括9名受访者报告的与度冷丁相关的惊厥和6人出现的成瘾问题。这些信息表明，在那些特别关注为镰状细胞病患儿提供医疗护理的机构中，人们使用了积极的疼痛控制方法。
