Christenson J T, al-Sarraf A, Abu-Saleh R
Department of Surgery, Faculty of Medicine, Kuwait University, Safat.
Arch Emerg Med. 1992 Mar;9(1):1-8. doi: 10.1136/emj.9.1.1.
The effects of low molecular weight dextran (LMWD) infusion, on gas exchange and haemodynamics were evaluated in sheep during endotoxin shock. The infusion of LMWD was started after signs of shock and lung injury were evident. After a stabilization period 10 micrograms kg-1 E. Coli endotoxin was infused i.v.. Endotoxin infusion resulted in an marked increase in pulmonary artery pressure (PAP) and decrease in mean arterial pressure (MAP), respiratory compliance, arterial oxygen tension (PaO2) and oxygen delivery index (DO2l). After 3 h MAP, PaO2, DO2l and compliance improved significantly in LMWD treated animals. The PAP had also decreased significantly in the LMWD-treated animals, but remained high in the controls (P less than 0.01). It was concluded that LMWD infusion improves haemodynamics and gas-exchange in sheep during endotoxin shock.
在内毒素休克期间，对绵羊输注低分子量右旋糖酐（LMWD），评估其对气体交换和血流动力学的影响。在休克和肺损伤迹象明显后开始输注LMWD。经过一段稳定期后，静脉内注入10微克/千克大肠杆菌内毒素。内毒素输注导致肺动脉压（PAP）显著升高，平均动脉压（MAP）、呼吸顺应性、动脉血氧分压（PaO2）和氧输送指数（DO2l）降低。3小时后，接受LMWD治疗的动物的MAP、PaO2、DO2l和顺应性显著改善。在接受LMWD治疗的动物中，PAP也显著降低，但在对照组中仍居高不下（P<0.01）。得出的结论是，在内毒素休克期间，输注LMWD可改善绵羊的血流动力学和气体交换。
