Fukai I, Masaoka A, Hashimoto T, Yamakawa Y, Mizuno T, Tanamura O, Hirokawa K, Ueda R
Second Department of Surgery, Nagoya City University Medical School, Japan.
Cancer. 1992 May 15;69(10):2463-8. doi: 10.1002/1097-0142(19920515)69:10<2463::aid-cncr2820691014>3.0.co;2-g.
Eighty-one cases of thymoma were studied immunohistologically with the use of three mouse monoclonal antibodies: one was specific for subcapsular-cortical, one for intra-cortical, and one for medullary epithelial cells. Twenty-eight (60.9%) of 46 polygonal cell thymomas were of the cortical type and 1 (2.2%) was of the medullary type. Ten (55.6%) of 18 spindle cell thymomas and 7 (41.2%) of 17 mixed cell thymomas were of the medullary type, and 1 (5.6%) of 18 spindle cell thymomas was of the cortical type. Fourteen (17.3%) of 81 thymomas were composed of epithelial cells that were triple positive immunologically; although these are unusual, they also may be present in the normal thymus. Based on these findings, triple-positive epithelium in the normal thymus consists of common stem cells that can differentiate into subcapsular-cortical, intra-cortical, and medullary epithelium; these cells may be the target cells for tumorigenesis. Epithelium in polygonal cell thymoma tends to differentiate into cortical epithelium, whereas epithelium in spindle and mixed cell thymomas differentiates into medullary epithelium.
利用三种小鼠单克隆抗体对81例胸腺瘤进行了免疫组织学研究：一种对被膜下皮质特异性，一种对皮质内特异性，一种对髓质上皮细胞特异性。46例多角形细胞胸腺瘤中，28例（60.9%）为皮质型，1例（2.2%）为髓质型。18例梭形细胞胸腺瘤中，10例（55.6%）为髓质型，17例混合细胞胸腺瘤中，7例（41.2%）为髓质型，18例梭形细胞胸腺瘤中，1例（5.6%）为皮质型。81例胸腺瘤中，14例（17.3%）由免疫反应呈三阳性的上皮细胞组成；虽然这些情况不常见，但也可能存在于正常胸腺中。基于这些发现，正常胸腺中的三阳性上皮由可分化为被膜下皮质、皮质内和髓质上皮的共同干细胞组成；这些细胞可能是肿瘤发生的靶细胞。多角形细胞胸腺瘤中的上皮倾向于分化为皮质上皮，而梭形和混合细胞胸腺瘤中的上皮则分化为髓质上皮。
