Jin H
Department of Otolaryngology, Hirosaki University, School of Medicine.
Nihon Jibiinkoka Gakkai Kaiho. 1992 Mar;95(3):391-9. doi: 10.3950/jibiinkoka.95.391.
The immunocytochemical distribution and morphological characteristics of substance P and neurofilament in vestibular end organs and the vestibular ganglion of the guinea pig were investigated. The effect of capsaicin on substance P-like immunoreactivity was also evaluated in this study. Substance P-like immunoreactivity was found in the peripheral region of vestibular end organs and in small or medium size vestibular ganglion cells. Approximately 85% of vestibular ganglion cells showed substance P-like immunoreactivity. Although substance P-like immunoreactivity was depleted in the nasal mucosa and trigeminal ganglion by capsaicin treatment, substance P distributed in the primary vestibular neurons was not affected. In contrast to the distribution of substance P, neurofilament was also found in the primary afferent neurons in the central regions of vestibular end organs. Neurofilament immunoreactive cells, which were larger in size than cells without neurofilament-like immunoreactivity comprised about 34% of vestibular ganglion cells. These immunocytochemical findings suggest that vestibular ganglion cells can be classified on the basis of size and immunocytochemical characteristics.
研究了豚鼠前庭终器和前庭神经节中P物质和神经丝的免疫细胞化学分布及形态学特征。本研究还评估了辣椒素对P物质样免疫反应性的影响。在前庭终器的周边区域以及中小尺寸的前庭神经节细胞中发现了P物质样免疫反应性。约85%的前庭神经节细胞显示出P物质样免疫反应性。虽然辣椒素处理使鼻黏膜和三叉神经节中的P物质样免疫反应性减少，但分布在前庭初级神经元中的P物质并未受到影响。与P物质的分布不同，在前庭终器中央区域的初级传入神经元中也发现了神经丝。神经丝免疫反应性细胞比无神经丝样免疫反应性的细胞大，约占前庭神经节细胞的34%。这些免疫细胞化学结果表明，前庭神经节细胞可根据大小和免疫细胞化学特征进行分类。
