Shapiro E, Becich M J, Hartanto V, Lepor H
Department of Urology, Medical College of Wisconsin, Milwaukee 53226.
J Urol. 1992 May;147(5):1293-7. doi: 10.1016/s0022-5347(17)37546-8.
The specific features of the prostate adenoma predisposing to the development of symptomatic benign prostatic hyperplasia (BPH) are unknown. Our objective was to determine whether the histological composition of the prostate adenoma is related to the development of symptomatic BPH. Prostate adenomas were obtained from men with asymptomatic BPH undergoing cystoprostatectomy for invasive transitional cell carcinoma, and from men with symptomatic BPH undergoing open prostatectomy, transurethral resection of the prostate and pharmacotherapy. The severity of bladder outlet obstruction was evaluated with the Boyarsky symptom score and uroflowmetry. The percentages of stroma, epithelium and glandular lumen were determined in the prostate adenomas via quantitative image analysis on a computer-assisted morphometry system. The prostate adenomas from the 33 men with symptomatic BPH contained 62 +/- 1%, 15 +/- 1% and 23 +/- 1 of stroma, epithelium and glandular lumen, respectively. The prostate adenomas from 6 men with asymptomatic disease contained 54 +/- 1%, 21 +/- 1% and 25 +/- 1% of stroma, epithelium and glandular lumen, respectively. The ratios of stromal-to-epithelial hyperplasia in the prostate adenomas from men with symptomatic and asymptomatic disease were 4.6 +/- 0.3 and 2.7 +/- 0.1, respectively. The differences in percentage of stroma and epithelium, and the stromal-to-epithelial ratio in the prostate adenomas from men with symptomatic and asymptomatic BPH were statistically significant. Our study suggests that the histological composition of the prostate adenoma is related to the development of symptomatic BPH.
易引发有症状良性前列腺增生（BPH）的前列腺腺瘤的具体特征尚不清楚。我们的目的是确定前列腺腺瘤的组织学组成是否与有症状BPH的发生有关。前列腺腺瘤取自因浸润性移行细胞癌接受膀胱前列腺切除术的无症状BPH男性，以及接受开放性前列腺切除术、经尿道前列腺切除术和药物治疗的有症状BPH男性。采用博亚尔斯基症状评分和尿流率测定评估膀胱出口梗阻的严重程度。通过计算机辅助形态测量系统的定量图像分析确定前列腺腺瘤中基质、上皮和腺腔的百分比。33例有症状BPH男性的前列腺腺瘤中，基质、上皮和腺腔分别占62±1%、15±1%和23±1%。6例无症状疾病男性的前列腺腺瘤中，基质、上皮和腺腔分别占54±1%、21±1%和25±1%。有症状和无症状疾病男性的前列腺腺瘤中基质与上皮增生的比例分别为4.6±0.3和2.7±0.1。有症状和无症状BPH男性的前列腺腺瘤中基质和上皮百分比以及基质与上皮比例的差异具有统计学意义。我们的研究表明，前列腺腺瘤的组织学组成与有症状BPH的发生有关。
