Graf U, Heo O S, Ramirez O O
Institute of Toxicology, Swiss Federal Institute of Technology, Schwerzenbach.
Mutat Res. 1992 Apr;266(2):197-203. doi: 10.1016/0027-5107(92)90187-7.
Chromium(VI) oxide and chromium(III) chloride were tested in the wing somatic mutation and recombination test (SMART) in Drosophila melanogaster according to standard procedures. The hexavalent compound was highly genotoxic in both chronic and acute treatments whereas the trivalent one was clearly negative. Further analysis of wings carrying an inversion chromosome which eliminates all recombination events showed that over 90% of the spots induced by chromium(VI) oxide are due to mitotic recombination.
按照标准程序，在黑腹果蝇的翅体细胞突变和重组试验（SMART）中对氧化铬（VI）和氯化铬（III）进行了测试。六价化合物在慢性和急性处理中均具有高度遗传毒性，而三价化合物则明显呈阴性。对携带消除所有重组事件的倒位染色体的翅膀进行进一步分析表明，氧化铬（VI）诱导的斑点中超过90%是由于有丝分裂重组所致。
