Mateos S, Panneerselvam N, Mateos J C, Cortés F
Department of Cell Biology, Faculty of Biology, Sevilla, Spain.
Mutat Res. 1992 Apr;266(2):215-9. doi: 10.1016/0027-5107(92)90189-9.
X-Ray-induced chromosomal aberrations (CA) were potentiated by post-treatments in G2 with either caffeine (caff) or poly-D-lysine (PDL) in root-tip cells of Allium cepa. The enhancement of the yield of CA was concomitant with an increase in the frequency of mitosis. Our results seem to support the idea of a direct relationship between radiation-induced G2 delay and repair of chromosome damage. Here we report on similarities between caffeine and PDL in both decreasing G2 delay and enhancing chromatid aberration yield. The possible molecular mechanism(s) of action responsible for the cytogenetic effects observed are discussed.
在洋葱根尖细胞中，用咖啡因（caff）或聚-D-赖氨酸（PDL）在G2期进行后处理，可增强X射线诱导的染色体畸变（CA）。CA产量的增加与有丝分裂频率的增加相伴。我们的结果似乎支持辐射诱导的G2期延迟与染色体损伤修复之间存在直接关系的观点。在此，我们报告咖啡因和PDL在减少G2期延迟和提高染色单体畸变产量方面的相似性。还讨论了观察到的细胞遗传学效应的可能分子作用机制。
