Chopko B W, Voneida T J
Department of Neurobiology, Northeastern Ohio Universities College of Medicine, Rootstown 44272-9989.
J Neural Transplant Plast. 1992 Jan-Mar;3(1):63-9. doi: 10.1155/NP.1992.63.
Fragments of fetal rat cerebellar tissue were grafted into forebrain cortical lesion cavities of adult rats. After a survival ranging from 12-151 days, no graft was found to fill the cavity completely. Large neurons, occasionally grouped into nests, were identifiable from the 22nd day. Myelinated graft fibers, first seen at 32 days, failed to enter host brain. Although grafts demonstrated elements resembling cerebellar tissue, overall organization did not resemble that of the cerebellum.
将胎鼠小脑组织碎片移植到成年大鼠的前脑皮质损伤腔中。在存活12至151天后,未发现移植物完全填充腔隙。从第22天起可识别出大型神经元,偶尔聚集成巢状。有髓鞘的移植纤维在第32天首次出现,但未能进入宿主脑内。尽管移植物显示出类似小脑组织的成分,但其整体结构与小脑并不相似。