胰岛素相关肽在蜗牛（Helix aspersa Müller）中枢神经系统中的免疫细胞化学定位：参与生长控制
Immunocytochemical localization of insulin-related peptide(s) in the central nervous system of the snail Helix aspersa Müller: involvement in growth control.
作者信息
Gomot A, Gomot L, Marchand C R, Colard C, Bride J
机构信息
Laboratoire de Zoologie et Embryologie, URA CNRS 687, Faculté des Sciences, Besançon, France.
出版信息
Cell Mol Neurobiol. 1992 Feb;12(1):21-32. doi: 10.1007/BF00711636.
Abstract
- The presence of insulin-like substances has been demonstrated by immunocytochemistry in the central nervous system of the snail Helix aspersa. 2. The immunopositivity has been observed especially in the large perikarya of the mesocerebral green cells [the cerebral green cells (CeGC) stained in green by the alcian blue:alcian yellow technique]. 3. The removal of either the mesocerebrum or the CeGC stops the growth of the snail and induces the increase of the glycogen content in the mantle edge. 4. Our results show the existence of insulin-like material in the neurosecretory cells. Previous data having demonstrated the presence of specific binding sites to insulin in the cephalic ganglia of Helix aspersa, one may suggest that insulin could play a neuromodulatory or a neurotransmittory role in the central nervous system and might control the growth.
摘要
- 通过免疫细胞化学方法已证实在蜗牛（Helix aspersa）的中枢神经系统中存在胰岛素样物质。2. 尤其在中脑绿色细胞的大型胞体中观察到免疫阳性反应[通过阿尔辛蓝：阿尔辛黄技术染成绿色的脑绿色细胞（CeGC）]。3. 切除中脑或CeGC会阻止蜗牛生长，并导致外套膜边缘糖原含量增加。4. 我们的结果表明神经分泌细胞中存在胰岛素样物质。先前的数据已证明在Helix aspersa的脑神经节中存在胰岛素的特异性结合位点，因此可以推测胰岛素可能在中枢神经系统中发挥神经调节或神经传递作用，并可能控制生长。
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本文引用的文献
1
Unique features of the insulin receptor in rat brain.
J Neurochem. 1984 Nov;43(5):1302-9. doi: 10.1111/j.1471-4159.1984.tb05387.x.
2
Insulin binding in four regions of the developing rat brain.
J Neurochem. 1984 Jan;42(1):198-203. doi: 10.1111/j.1471-4159.1984.tb09717.x.
3
A comparative study on neurosecretion demonstrated by the alcian blue-alcian yellow technique in three terrestrial pulmonates (Stylommatophora).
Cell Tissue Res. 1980;210(1):47-56. doi: 10.1007/BF00232140.
4
Immunocytochemical demonstration of peptidergic neurons in the central nervous system of the pond snail Lymnaea stagnalis with antisera raised to biologically active peptides of vertebrates.
Cell Tissue Res. 1981;216(2):273-91. doi: 10.1007/BF00233620.
5
Estimation of glycogen in small amounts of tissue.
Anal Biochem. 1965 May;11(2):256-65. doi: 10.1016/0003-2697(65)90013-8.
6
Ultrastructure and histochemistry of neurosecretory cells and neurohaemal areas in the pond snail Lymnaea stagnalis (L.).
Z Zellforsch Mikrosk Anat. 1970;108(2):190-224. doi: 10.1007/BF00335295.
7
Molecular properties of various snail peptides from brain and gut.
Peptides. 1985;6 Suppl 3:451-7. doi: 10.1016/0196-9781(85)90413-9.
8
Insulin receptors and insulin modulation of norepinephrine uptake in neuronal cultures from rat brain.
J Biol Chem. 1985 Dec 15;260(29):15880-4.
9
Light and electron microscopic analysis of insulin binding sites on neurons in dissociated brain cell cultures.
Brain Res Bull. 1985 May;14(5):415-21. doi: 10.1016/0361-9230(85)90018-8.
10
Brain cells that command sexual behavior in the snail Helix aspersa.
J Neurobiol. 1986 Nov;17(6):669-79. doi: 10.1002/neu.480170610.
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