Goudsmit J
Human Retrovirus Laboratory, Academic Medical Center, Amsterdam, The Netherlands.
Int Rev Immunol. 1992;8(1):65-81. doi: 10.3109/08830189209056642.
An attempt is made to summarize the evidence that humoral immune responses in natural HIV-1 infection play a role in clearance of the initial burst of replication as well as in protection against rapid disease progression. Therefore, the so-called "asymptomatic carrier state" was defined on the basis of immunological characteristics, such as CD4+ cell number, CD45RA-CD29+ cell number, CD4+ proliferative responses to anti-CD3 mAbs and soluble activation markers, as well as virological characteristics such as the state of the viral genome in the cell, levels of genomic RNA production, antigenemia, viremia and virus phenotype. During natural infection two major classes HIV-1 neutralizing and cell-fusion inhibiting antibodies are elicited. One population directed against mostly continuous epitopes localized in the third variable domain (V3) of the envelope and one against discontinuous epitopes of the envelope. The last population blocks gp120-CD4 attachment, the first does not. The role of each of these populations of functional antibodies, in the clearance of viremia and the maintenance of the asymptomatic carrier state is discussed.
本文试图总结相关证据，即自然HIV-1感染中的体液免疫反应在清除初始爆发性复制以及预防疾病快速进展方面发挥作用。因此，所谓的“无症状携带者状态”是根据免疫特征（如CD4+细胞数量、CD45RA-CD29+细胞数量、CD4+对抗CD3单克隆抗体和可溶性激活标志物的增殖反应）以及病毒学特征（如细胞内病毒基因组状态、基因组RNA产生水平、抗原血症、病毒血症和病毒表型）来定义的。在自然感染过程中，会产生两大类HIV-1中和抗体和细胞融合抑制抗体。一类主要针对包膜第三可变区（V3）中大多连续的表位，另一类针对包膜的不连续表位。后一类抗体阻断gp120-CD4结合，前一类则不然。本文讨论了这些功能性抗体群体在清除病毒血症和维持无症状携带者状态中的作用。
