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躁狂症中的红细胞膜阳离子载体

Erythrocyte membrane cation carrier in mania.

作者信息

Naylor G J, Dick D A, Dick E G, Worrall E P, Peet M, Dick P, Boardman L J

出版信息

Psychol Med. 1976 Nov;6(4):659-63. doi: 10.1017/s0033291700018316.

DOI:10.1017/s0033291700018316
PMID:137413
Abstract

Erythrocyte sodium and potassium concentrations, erythrocyte membrane ATPase (Na-K specific and non-specific) and the rate of potassium influx into erythrocytes (ouabain-sensitive and insensitive) were estimated in a group of female patients suffering from mania and repeated on about two thirds of them when they had recovered. With recovery there was a statistically significant increase in the erythrocyte ouabain-sensitive potassium influx. The other parameters showed no significant overall change with recovery but the initial severity correlated significantly and negatively with the change in erythrocyte Na-K ATPase with recovery. The changes that occurred in the erythorcyte sodium concentration and Na-K ATPase activity were not random since they correlated significantly with changes in the active potassium influx.

摘要

对一组躁狂症女性患者的红细胞钠和钾浓度、红细胞膜ATP酶(钠钾特异性和非特异性)以及钾流入红细胞的速率(哇巴因敏感和不敏感)进行了评估,并在其中约三分之二的患者康复时再次进行评估。随着康复,红细胞哇巴因敏感的钾流入量有统计学意义的增加。其他参数在康复时总体上没有显著变化,但初始严重程度与康复时红细胞钠钾ATP酶的变化呈显著负相关。红细胞钠浓度和钠钾ATP酶活性发生的变化并非随机,因为它们与活性钾流入的变化显著相关。

相似文献

1
Erythrocyte membrane cation carrier in mania.躁狂症中的红细胞膜阳离子载体
Psychol Med. 1976 Nov;6(4):659-63. doi: 10.1017/s0033291700018316.
2
Lithium and erythrocyte membrane cation carrier studies in normal and manic depressive subjects.
Psychol Med. 1977 May;7(2):229-33. doi: 10.1017/s0033291700029305.
3
Erythrocyte membrane cation carrier in depressive illness.
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Erythrocyte membrane cation carrier, relapse rate of manic-depressive illness and response to lithium.
Psychol Med. 1976 May;6(2):257-63. doi: 10.1017/s0033291700013805.
5
[The effect of membrane-bound calcium on the activity of adenosine triphosphatase from erythrocytes and erythrocyte permeability for monovalent cations].[膜结合钙对红细胞三磷酸腺苷酶活性及红细胞对单价阳离子通透性的影响]
Biokhimiia. 1978 Feb;43(2):208-15.
6
Changes in the erythrocyte sodium pump with age.红细胞钠泵随年龄的变化。
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The interaction of monovalent cations with the sodium pump of low-potassium goat erythrocytes.单价阳离子与低钾山羊红细胞钠泵的相互作用。
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引用本文的文献

1
The effects of serum, lithium, ethacrynic acid, and a low external concentration of potassium on specific [3H]-ouabain binding to human lymphocytes after incubation for 3 days.血清、锂、依他尼酸及低浓度细胞外钾对人淋巴细胞孵育3天后特异性[³H]哇巴因结合的影响。
Br J Clin Pharmacol. 1986 Sep;22(3):275-9. doi: 10.1111/j.1365-2125.1986.tb02887.x.
2
A study of the transport of lithium across the erythrocyte membrane in vivo and of the effects of the ion transport inhibitors digoxin and dipyridamole.一项关于锂在体内跨红细胞膜转运以及离子转运抑制剂地高辛和双嘧达莫作用的研究。
Br J Clin Pharmacol. 1989 Jun;27(6):749-56. doi: 10.1111/j.1365-2125.1989.tb03436.x.
3
The effect of oral salbutamol on cation transport measured in vivo in healthy volunteers.
口服沙丁胺醇对健康志愿者体内阳离子转运的影响。
Br J Clin Pharmacol. 1990 Sep;30(3):383-90. doi: 10.1111/j.1365-2125.1990.tb03788.x.