Granström M L, Gaily E
Children's Castle Hospital, Helsinki, Finland.
Neurology. 1992 Apr;42(4 Suppl 5):144-8.
The risk of psychomotor retardation and the prevalence of mental subnormality are slightly increased in offspring of mothers with epilepsy. The prevalence rates of mental deficiency observed in population-based studies have been lower than those in reports of hospital-based studies. In addition to use of antiepileptic drugs (AEDs), several other factors associated with maternal epilepsy, such as seizures during pregnancy, inherited brain disorders, and nonoptimal psychosocial environment, can affect the child's psychomotor development. None of the major AEDs carries any special risk for mental retardation. However, polytherapy and inherited deviations in AED metabolism in the fetus probably do increase the risk for mental retardation.
癫痫母亲的后代出现精神运动发育迟缓的风险及智力发育不全的患病率略有增加。基于人群的研究中观察到的智力缺陷患病率低于基于医院的研究报告中的患病率。除了使用抗癫痫药物（AEDs）外，与母亲癫痫相关的其他几个因素，如孕期癫痫发作、遗传性脑部疾病和不理想的心理社会环境，都可能影响孩子的精神运动发育。没有一种主要的抗癫痫药物会带来任何特殊的智力发育迟缓风险。然而，联合治疗以及胎儿抗癫痫药物代谢的遗传偏差可能确实会增加智力发育迟缓的风险。
