Amplification of the dihydrofolate reductase gene in methotrexate-resistant Chinese hamster cells. - Suppr | 超能文献

Amplification of the dihydrofolate reductase gene in methotrexate-resistant Chinese hamster cells.

作者信息

Hamlin J L

机构信息

Department of Biochemistry, University of Virginia School of Medicine, Charlottesville 22908.

出版信息

Mutat Res. 1992 May;276(3):179-87. doi: 10.1016/0165-1110(92)90007-v.

DOI:10.1016/0165-1110(92)90007-v

Abstract

摘要

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Amplification of the dihydrofolate reductase gene in methotrexate-resistant Chinese hamster cells.

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[Localization of dihydrofolate reductase amplified genes in Chinese hamster cells resistant to methotrexate].[二氢叶酸还原酶扩增基因在中国仓鼠甲氨蝶呤抗性细胞中的定位]

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Assignment of the native Chinese hamster dihydrofolate reductase gene to chromosome 2.中国仓鼠二氢叶酸还原酶基因定位于2号染色体

Cytogenet Cell Genet. 1983;36(4):599-604. doi: 10.1159/000131982.

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Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line.中国仓鼠卵巢细胞系中二氢叶酸还原酶基因的扩增与缺失

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Sequential amplification of dihydrofolate reductase and multidrug resistance genes in Chinese hamster ovary cells selected for stepwise resistance to the lipid-soluble antifolate trimetrexate.在中国仓鼠卵巢细胞中，对脂溶性抗叶酸药物三甲曲沙逐步产生抗性的过程中，二氢叶酸还原酶和多药耐药基因的序列扩增。

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Overproduction of dihydrofolate reductase and gene amplification in methotrexate-resistant Chinese hamster ovary cells.甲氨蝶呤耐药的中国仓鼠卵巢细胞中二氢叶酸还原酶的过量产生与基因扩增

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The dihydrofolate reductase amplicons in different methotrexate-resistant Chinese hamster cell lines share at least a 273-kilobase core sequence, but the amplicons in some cell lines are much larger and are remarkably uniform in structure.不同甲氨蝶呤抗性中国仓鼠细胞系中的二氢叶酸还原酶扩增子至少共享一个273千碱基的核心序列，但某些细胞系中的扩增子要大得多，且结构非常一致。

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Similar 150-kilobase DNA sequences are amplified in independently derived methotrexate-resistant Chinese hamster cells.在独立衍生的耐甲氨蝶呤中国仓鼠细胞中扩增出了相似的150千碱基DNA序列。

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Studies on the amplification of dihydrofolate reductase genes in methotrexate-resistant cultured mouse cells.

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Multiple origins of replication in the dihydrofolate reductase amplicons of a methotrexate-resistant chinese hamster cell line.甲氨蝶呤抗性中国仓鼠细胞系二氢叶酸还原酶扩增子中的多个复制起点

Mol Cell Biol. 1990 Apr;10(4):1338-46. doi: 10.1128/mcb.10.4.1338-1346.1990.

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