Weitz J I, Hirsh J
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Annu Rev Med. 1992;43:9-16. doi: 10.1146/annurev.me.43.020192.000301.
The inhibition of thrombin is the key to the prevention and treatment of thrombotic disorders. Although heparin is an extremely effective anticoagulant, it has certain limitations that are not shared by newer thrombin inhibitors. As a result, these novel inhibitors may have advantages over heparin in certain clinical settings.
抑制凝血酶是预防和治疗血栓性疾病的关键。尽管肝素是一种极其有效的抗凝剂,但它有一些新型凝血酶抑制剂所没有的局限性。因此,这些新型抑制剂在某些临床情况下可能比肝素更具优势。