基于对三条染色体上基因座的限制性片段长度多态性（RFLP）和单倍型分析的海洋种群的遗传亲缘关系。

Genetic affinities of oceanic populations based on RFLP and haplotype analysis of genetic loci on three chromosomes.

作者信息

Chen L Z, Easteal S, Board P G, Kirk R L

机构信息

Human Genetics Group, John Curtin School of Medical Research, Australian National University, Canberra, ACT.

出版信息

Hum Biol. 1992 Feb;64(1):1-15.

PMID:1374731

Abstract

Restriction fragment length polymorphisms at the renin and factor 13B loci located at chromosome 1q32-1q42 were studied in 14 ethnic groups in the west Pacific region. The allele frequencies were combined with previously described beta-globin and albumin-vitamin D binding protein haplotype frequencies and used to assess genetic affinities among eight major ethnic-geographic groups in this region. These population groups divide into two clusters with Australian Aborigines, Island Melanesians, and Highland Melanesians forming one cluster and east Asians, Southeast Asians, Micronesians, and Polynesians forming the other. The results indicate that Micronesians and Polynesians are derived from populations in Southeast Asia and that they originated independently of the Melanesian populations.

摘要

对位于1号染色体1q32 - 1q42的肾素和凝血因子13B基因座的限制性片段长度多态性进行了研究，涉及西太平洋地区的14个民族。将等位基因频率与先前描述的β-珠蛋白和白蛋白 - 维生素D结合蛋白单倍型频率相结合，用于评估该地区八个主要民族地理群体之间的遗传亲缘关系。这些人群分为两个聚类，澳大利亚原住民、美拉尼西亚岛民和高地美拉尼西亚人形成一个聚类，东亚人、东南亚人、密克罗尼西亚人和波利尼西亚人形成另一个聚类。结果表明，密克罗尼西亚人和波利尼西亚人源自东南亚人群，并且他们独立于美拉尼西亚人群起源。