抑肽酶（胰蛋白酶抑制剂）对接触因子（凝血因子 XII）激活的抑制作用。
Inhibition of the activation of Hageman factor (factor XII) by aprotinin (Trasylol).
作者信息
Laurel M T, Ratnoff O D, Everson B
机构信息
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
出版信息
J Lab Clin Med. 1992 May;119(5):580-5.
PMID:1374787
Abstract
Aprotinin (Trasylol; Bayer AG, Leverkusen, Germany), a protease inhibitor resembling or identical with Kunitz' pancreatic trypsin inhibitor, is said to have anticoagulant properties, but these are not clearly defined. The present study provides evidence that one action of aprotinin is inhibition of the activation of Hageman factor (factor XII).
摘要
抑肽酶（商品名：Trasylol；德国拜耳公司，勒沃库森）是一种类似于或等同于库尼茨胰腺胰蛋白酶抑制剂的蛋白酶抑制剂，据说具有抗凝特性，但这些特性尚未明确界定。本研究提供了证据，表明抑肽酶的一种作用是抑制哈格曼因子（因子Ⅻ）的激活。
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