Ohlund L S, Lindström L H, Ohman A
Department of Clinical Psychology, University of Uppsala, Sweden.
J Nerv Ment Dis. 1992 May;180(5):304-13.
The present study was designed to examine the relationship between electrodermal activity and the levels of the dopamine metabolite homovanillic acid (HVA) and the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in cerebrospinal fluid. Lumbar cerebrospinal fluid from 36 unmedicated and six medicated schizophrenic patients and 23 controls was analyzed by gas chromatograph-mass spectrometer. The schizophrenic patients and a group of 14 normal controls were presented with a series of orienting tones (1000 Hz, 80 db, 2-second duration) while electrodermal activity was monitored. For the patients, this occurred during an acute episode of schizophrenia. The results suggest an inverse relation between electrodermal activity and the CSF-level of HVA. Although the picture is not entirely consistent, electrodermal nonresponders appear to have normal HVA levels, while electrodermal responders have decreased levels compared with normal controls. There is also a relation between electrodermal activity and 5-HIAA, but this association is not as clear-cut as the one between electrodermal activity and HVA.
本研究旨在探讨皮肤电活动与脑脊液中多巴胺代谢产物高香草酸（HVA）及5-羟色胺代谢产物5-羟吲哚乙酸（5-HIAA）水平之间的关系。采用气相色谱-质谱联用仪对36例未用药的精神分裂症患者、6例用药的精神分裂症患者及23名对照者的腰椎脑脊液进行了分析。在监测皮肤电活动的同时，向精神分裂症患者及一组14名正常对照者呈现一系列定向音（1000赫兹、80分贝、持续2秒）。对患者而言，这一过程发生在精神分裂症急性发作期。结果表明，皮肤电活动与脑脊液中HVA水平呈负相关。尽管情况并非完全一致，但皮肤电无反应者的HVA水平似乎正常，而与正常对照相比，皮肤电反应者的HVA水平有所降低。皮肤电活动与5-HIAA之间也存在关系，但这种关联不如皮肤电活动与HVA之间的关联那么明确。
