Fleming L W, Stewart W K, Parratt D
Department of Medicine, University of Dundee, Ninewells Hospital and Medical School, Scotland, UK.
Nephrol Dial Transplant. 1992;7(1):35-9.
Serum immune complexes, plasma dextran antibodies and percentage conversion of complement have been measured in 20 dialysed patients before and after an intravenous infusion of iron dextran providing 600 mg elemental iron. Complement conversion was unmeasurable and there were no changes in circulating immune complexes. The presence of dextran antibodies in nine patients before the infusion was not related to prior exposure to iron dextran. They became undetectable in these patients within hours after the infusion, reappearing 1 month later in three. Two of three patients reporting mild aches and shivers on the day following the infusion had no detectable dextran antibodies. An adverse reaction involving inflamed joints occurred 1-2 days after a second infusion given to one of the patients studied above. The parameters under study were again measured and did not appear to relate to the reaction. The presence of dextran antibodies does not preclude the giving of iron dextran to patients on dialysis, and the immune complex and complement systems remain undisturbed by iron dextran infusions.
在20名接受透析的患者静脉输注提供600毫克元素铁的右旋糖酐铁前后，检测了血清免疫复合物、血浆右旋糖酐抗体和补体转化率。补体转化率无法测量，循环免疫复合物也没有变化。9名患者在输注前存在右旋糖酐抗体，这与之前接触右旋糖酐铁无关。输注后数小时内，这些患者体内的右旋糖酐抗体无法检测到，1个月后，其中3名患者的抗体再次出现。在输注后第二天报告有轻度疼痛和寒战的3名患者中，有2名没有可检测到的右旋糖酐抗体。上述研究的一名患者在第二次输注后1 - 2天出现了涉及关节炎症的不良反应。再次测量了所研究的参数，这些参数似乎与该反应无关。右旋糖酐抗体的存在并不妨碍给透析患者输注右旋糖酐铁，免疫复合物和补体系统也不受右旋糖酐铁输注的干扰。
