白细胞介素-6降低了急性髓细胞白血病患者白血病原始祖细胞的体外最佳生长能力。
Interleukin-6 reduces the optimal growth in vitro of leukemic blast progenitors from acute myeloblastic leukemia patients.
作者信息
Suzuki T, Bessho M, Hirashma K, Tohda S, Nagata K, Imai Y, Nara N
机构信息
1st Department of Internal Medicine, Saitama Medical School, Japan.
出版信息
Acta Haematol. 1992;87(1-2):63-8. doi: 10.1159/000204718.
The combined effects of five cytokines; recombinant human (rHu) granulocyte colony-stimulating factor (G-CSF), rHu granulocyte-macrophage colony-stimulating factor (GM-CSF), rHu interleukin-1 beta (IL-1 beta), rHu interleukin-3 (IL-3), and rHu interleukin-6 (IL-6) on blast colony formation in methylcellulose by leukemic blast progenitors from 10 patients with acute myeloblastic leukemia (AML) were studied. Combination of G-CSF, GM-CSF, IL-1 beta, and IL-3 stimulated maximum blast colony formation in 9 patients. Further addition of IL-6 reduced the combined effect of the four cytokines on blast colony formation. IL-6 regulates the proliferation of leukemic blast progenitors and may play an important role in the regulation of hematopoiesis.
研究了五种细胞因子，即重组人（rHu）粒细胞集落刺激因子（G-CSF）、rHu粒细胞-巨噬细胞集落刺激因子（GM-CSF）、rHu白细胞介素-1β（IL-1β）、rHu白细胞介素-3（IL-3）和rHu白细胞介素-6（IL-6）对10例急性髓细胞白血病（AML）患者白血病原始祖细胞在甲基纤维素中形成原始集落的联合作用。G-CSF、GM-CSF、IL-1β和IL-3的组合刺激了9例患者的最大原始集落形成。进一步添加IL-6降低了这四种细胞因子对原始集落形成的联合作用。IL-6调节白血病原始祖细胞的增殖，可能在造血调节中起重要作用。
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