Suzuki T, Bessho M, Hirashma K, Tohda S, Nagata K, Imai Y, Nara N
1st Department of Internal Medicine, Saitama Medical School, Japan.
Acta Haematol. 1992;87(1-2):63-8. doi: 10.1159/000204718.
The combined effects of five cytokines; recombinant human (rHu) granulocyte colony-stimulating factor (G-CSF), rHu granulocyte-macrophage colony-stimulating factor (GM-CSF), rHu interleukin-1 beta (IL-1 beta), rHu interleukin-3 (IL-3), and rHu interleukin-6 (IL-6) on blast colony formation in methylcellulose by leukemic blast progenitors from 10 patients with acute myeloblastic leukemia (AML) were studied. Combination of G-CSF, GM-CSF, IL-1 beta, and IL-3 stimulated maximum blast colony formation in 9 patients. Further addition of IL-6 reduced the combined effect of the four cytokines on blast colony formation. IL-6 regulates the proliferation of leukemic blast progenitors and may play an important role in the regulation of hematopoiesis.
研究了五种细胞因子，即重组人（rHu）粒细胞集落刺激因子（G-CSF）、rHu粒细胞-巨噬细胞集落刺激因子（GM-CSF）、rHu白细胞介素-1β（IL-1β）、rHu白细胞介素-3（IL-3）和rHu白细胞介素-6（IL-6）对10例急性髓细胞白血病（AML）患者白血病原始祖细胞在甲基纤维素中形成原始集落的联合作用。G-CSF、GM-CSF、IL-1β和IL-3的组合刺激了9例患者的最大原始集落形成。进一步添加IL-6降低了这四种细胞因子对原始集落形成的联合作用。IL-6调节白血病原始祖细胞的增殖，可能在造血调节中起重要作用。
