Tousch-Connier-Blanc M A
Rev Stomatol Chir Maxillofac. 1976 Jul-Aug;77(5):721-6.
Cutaneous accidents due to sulfonamides have been known since 1939 and their frequency is about 1%. Allergy to a sulfonamide definitely excludes the use of all the others and causes allergy to the amine group in para: anaesthesia of the procaine type, PAS, aniline dyes, synthetic sweeteners, and hair dyes. There is no correlation between the amount ingested and the severity of the accidents. Clinically, these accidents are very polymorphous ranging from photosensitization to eruptions as serious as acute epidermal necrosis.
自1939年以来，人们就已熟知磺胺类药物引起的皮肤不良反应，其发生率约为1%。对一种磺胺类药物过敏绝对排除使用所有其他磺胺类药物，并会导致对对位氨基过敏：普鲁卡因类麻醉药、对氨基水杨酸、苯胺染料、合成甜味剂和染发剂。摄入剂量与不良反应的严重程度之间没有关联。临床上，这些不良反应多种多样，从光敏反应到严重如急性表皮坏死的皮疹。
