Kobayashi K
Department of Laboratory Medicine, Hokkaido University School of Medicine, Sapporo.
Rinsho Byori. 1992 Apr;40(4):385-91.
A brief commentary on leukocyte adhesion molecules, including integrin family, immunoglobulin superfamily and selectin or LEC-CAM family is made. A recent concept on the molecular mechanisms of the leukocyte adhesion to cell surface is also described. An immunodeficiency disease called "leukocyte adhesion deficiency (LAD)" that is defective in expression of leukocyte adhesion molecules of integrin family, LFA-1, Mac-1 and p150, 95, is discussed with special reference to its clinical features, laboratory findings, neutrophil functions, lymphocyte functions and molecular defects. Some abnormal expression of a Fc-gamma receptor in neutrophils and new data concerning the molecular defects found in Japanese patients are also included.
本文简要评述了白细胞黏附分子，包括整合素家族、免疫球蛋白超家族和选择素或凝集素细胞黏附分子家族（LEC-CAM家族）。还介绍了白细胞黏附到细胞表面分子机制的最新概念。讨论了一种称为“白细胞黏附缺陷症（LAD）”的免疫缺陷疾病，该疾病在整合素家族白细胞黏附分子LFA-1、Mac-1和p150、95的表达上存在缺陷，并特别提及了其临床特征、实验室检查结果、中性粒细胞功能、淋巴细胞功能及分子缺陷。文中还包括了中性粒细胞中Fc-γ受体的一些异常表达情况以及在日本患者中发现的分子缺陷的新数据。
