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一种识别HIV-1 p24核心蛋白上福尔马林抗性表位的单克隆抗体。

A monoclonal antibody that recognizes a formalin-resistant epitope on the p 24 core protein of HIV-1.

作者信息

Kaluza G, Willems W R, Lohmeyer J, Altmannsberger M, Bohle R M, Lübke S

机构信息

Institut für Med. Virologie, Justus-Liebig-Universität, Giessen, FRG.

出版信息

Pathol Res Pract. 1992 Feb;188(1-2):91-6. doi: 10.1016/s0344-0338(11)81162-3.

DOI:10.1016/s0344-0338(11)81162-3
PMID:1375742
Abstract

A murine monoclonal antibody (called H-11) that binds to the p 24 core protein of HIV-1 was characterized by radioimmuno-precipitation, immunofluorescence, western blot assays, immunocytochemistry and immunohistochemistry. This antibody was found to be especially suited for demonstrating the presence of HIV-1 in formalin-fixed, paraffin-embedded tissues.

摘要

一种与HIV-1的p24核心蛋白结合的鼠单克隆抗体(称为H-11),通过放射免疫沉淀、免疫荧光、蛋白质印迹分析、免疫细胞化学和免疫组织化学进行了表征。发现该抗体特别适合用于证明福尔马林固定、石蜡包埋组织中HIV-1的存在。

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