Hurt M A, Hardarson S, Stadecker M J, Santa Cruz D J
Department of Pathology, University of Texas, Health Science Center, San Antonio.
J Cutan Pathol. 1992 Apr;19(2):134-41. doi: 10.1111/j.1600-0560.1992.tb01355.x.
We describe two patients with crusted perineal plaques that were biopsied and diagnosed as Paget's disease. Resection specimens of each contained a dermal mucinous carcinoma with extensive epidermotropism and coexistent epidermal basaloid proliferations closely resembling fibroepithelioma (Pinkus). The presence of the Paget phenomenon was supported by histochemical, immunohistochemical, and ultrastructural evidence. No other primary neoplasms were found in either patient. Followup at 2 1/2 and 3 1/2 years, respectively, has been negative. We conclude that either the fibroepitheliomatous changes may be induced by or may represent a collison (unlikely) with the epidermotropic mucinous carcinoma. It is proposed that the concept fibroepitheliomatous Paget phenomenon be used to stand for the histologic changes common to our cases as well as those previously reported.
我们描述了两名患有结痂性会阴斑块的患者，对其进行活检后诊断为佩吉特病。每个患者的切除标本均包含真皮黏液癌，伴有广泛的表皮内浸润以及与纤维上皮瘤（平卡斯型）极为相似的共存表皮基底样增生。组织化学、免疫组织化学及超微结构证据均支持佩吉特现象的存在。两名患者均未发现其他原发性肿瘤。分别在2年半和3年半的随访中均未发现异常。我们得出结论，纤维上皮瘤样改变可能是由表皮内黏液癌诱导产生，或者可能代表与表皮内黏液癌的碰撞（可能性不大）。建议使用“纤维上皮瘤样佩吉特现象”这一概念来代表我们病例以及先前报道病例中常见的组织学改变。
