LENNARD-JONES J E, LONGMORE A J, NEWELL A C, WILSON C W, JONES F A
Gut. 1960 Sep;1(3):217-22. doi: 10.1136/gut.1.3.217.
Two consecutive trials of out-patient treatment for mild cases of active ulcerative colitis are described. In the first trial oral prednisone gave significantly better results than a placebo. In the second trial "salazopyrin" gave final results approaching those of prednisone, although over a longer time and with a higher incidence of unpleasant side-effects, but topical hydrocortisone gave disappointing results, probably because the technique of administration was not suitable for ordinary out-patient use.
本文描述了针对轻度活动性溃疡性结肠炎门诊治疗的两项连续试验。在第一项试验中，口服泼尼松的效果明显优于安慰剂。在第二项试验中，“柳氮磺胺吡啶”的最终效果接近泼尼松，尽管起效时间更长且不良反应发生率更高，但局部使用氢化可的松的效果令人失望，可能是因为给药技术不适合普通门诊使用。
