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Identification of cellular factors that recognize UV-damaged DNA in Drosophila melanogaster.

作者信息

Todo T, Ryo H

机构信息

Department of Radiation Biology, Faculty of Medicine, Osaka University, Japan.

出版信息

Mutat Res. 1992 Jan;273(1):85-93. doi: 10.1016/0921-8777(92)90052-5.

DOI:10.1016/0921-8777(92)90052-5
PMID:1376438
Abstract

Using a gel electrophoresis DNA band-shift assay, we have identified 2 DNA-binding protein complexes in wild-type Drosophila embryonic cells which have high affinity for UV-irradiated, double-stranded DNA. Screening of Drosophila mutants deficient in DNA repair led to the identification of 5 mutants which lacked either one of the 2 protein complexes. Four excision repair-deficient mutants (mus-201, phr, mus-308 and mus-205) lacked one protein complex (Factor 2). The other protein complex (Factor 1) was not detectable in the post-replication repair-deficient mutant mus-104. These findings might suggest the possible involvement of these gene products in lesion recognition and repair of UV-induced photoproducts in DNA.

摘要

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