Yamamoto G, Tanabe M, Hashimoto G, Yamamoto M
Acta Med Okayama. 1976 Aug;30(4):291-301.
Ferrous ion-induced lipid peroxidation in rat liver mitochondria has a lag in the induction period. The characteristics of the lag were investigated under various conditions. This lag period lengthened proportionally to increased temperature (4 degrees approximately 37 degrees C). In the presence of inorganic phosphate the lag period lengthened, reaching a maximum at about 20 degrees C, and then shortened with increased temperatute. Elongated lag periods were shown in heat-treated or protein digested mitochondria. Shortened lag periods were shown in snake venom-treated mitochondria. On the other hand, almost no lag was observed in the peroxidation of the lipid extracted from mitochondria. The lag period also varied with incubation temperature. The results suggested that certain factors, which determined lag of the induction period in membrane lipid peroxidation associate with reaction-temperature and the lipo-protein structure in mitochondrial membranes.
亚铁离子诱导的大鼠肝脏线粒体脂质过氧化在诱导期存在一个延迟。在各种条件下研究了该延迟的特征。这个延迟期与温度升高（约4℃至37℃）成比例地延长。在无机磷酸盐存在下，延迟期延长，在约20℃时达到最大值，然后随着温度升高而缩短。热处理或蛋白质消化的线粒体表现出延长的延迟期。蛇毒处理的线粒体表现出缩短的延迟期。另一方面，从线粒体中提取的脂质的过氧化几乎未观察到延迟。延迟期也随孵育温度而变化。结果表明，决定膜脂质过氧化诱导期延迟的某些因素与反应温度和线粒体膜中的脂蛋白结构有关。
