Ohsaki K, Saito R
Acta Med Okayama. 1976 Oct;30(5):321-39.
Over the past ten years, polyethylene tube, stainless steel wire and absorbable gelatin sponge have come to be used in middle ear surgery. A modified Williams' steel chamber with a transparent central area was embedded in a rabbit ear lobe surgically, and cross-sectioned polyethylene tube, stainless steel wire or absorbable gelatin sponge were inserted respectively. The in vivo tissue reaction to each of these installed materials was observed daily microscopically. Finally, in the case of both the cross-sectioned polyethylene tube and the stainless steel wire, the chambers were fixed with 10% formalin solution and the contents stained for histological study. The results were as follows: Absorbable gelatin sponge was absorbed completely by phagocytosis in 62 days. Polyethylene tube was encapsulated by a layer of fibroblasts by day 110 in one case and by day 140 in another case; these findings were confirmed histologically on day 110 and 281. Almost all the surface of the stainless steel wire was encapsulated by a layer consisting of giant cells, on which a dense fibrous layer was superimposed by day 82. It is concluded that polyethylene tube, stainless steel wire, and absorbable gelatin sponge should be well tolerated in middle ear surgery.
在过去十年中，聚乙烯管、不锈钢丝和可吸收明胶海绵已开始用于中耳手术。将一个带有透明中心区域的改良威廉姆斯钢腔通过手术植入兔耳垂，然后分别插入横截面聚乙烯管、不锈钢丝或可吸收明胶海绵。每天通过显微镜观察这些植入材料在体内的组织反应。最后，对于横截面聚乙烯管和不锈钢丝，用10%福尔马林溶液固定钢腔，并对内容物进行染色以进行组织学研究。结果如下：可吸收明胶海绵在62天内通过吞噬作用被完全吸收。在一个病例中，聚乙烯管在第110天被一层成纤维细胞包裹，在另一个病例中在第140天被包裹；这些结果在第110天和第281天通过组织学得到证实。到第82天，几乎所有不锈钢丝表面都被一层由巨细胞组成的层包裹，在其上叠加了一层致密的纤维层。结论是，聚乙烯管、不锈钢丝和可吸收明胶海绵在中耳手术中应具有良好的耐受性。
