Kofler M, Saltuari L, Schmutzhard E, Berek K, Baumgartner H, Russegger L, Aichner F
Department of Neurology, Innsbruck University, Austria.
Electroencephalogr Clin Neurophysiol. 1992 Jul;83(1):83-6. doi: 10.1016/0013-4694(92)90136-6.
Multimodality evoked potentials were examined in a case of serious accidental intrathecal baclofen overdose in a patient who suffered from severe spasticity due to a traumatic brain lesion. Electrophysiological findings during, before and after the intoxication were compared. Transcranial electrical stimulation up to 750 V did not evoke any responses in thenar muscles on the first day of intoxication. An improvement to normal values was observed within 3 days, paralleled by an amelioration of the patient's clinical condition. Cervical electrical stimulation was largely unaffected by baclofen. Median nerve somatosensory and brain-stem acoustic evoked potentials revealed few or no differences during intoxication compared to pre- and post-intoxication responses.
