Suzawa H, Ichikawa K, Kikuchi S, Yamada K, Tsuchiya O, Hamano S, Komatsu H, Miyata H
Medical information, Kissei Pharmaceutical Co., Ltd., Matsumoto, Japan.
Nihon Yakurigaku Zasshi. 1992 Apr;99(4):241-6. doi: 10.1254/fpj.99.241.
We studied the effect of tranilast on the growth of carrageenin-induced granulation and the increase in capillary permeability induced by inflammatory agents in rats. In the carrageenin-induced granulation model, tranilast (50 or 100-200 mg/kg, p.o.) decreased significantly and dose-dependently the weight and the hydroxyproline content of the granulation tissue. Tranilast, however, showed no effect on the healing day of locally wounded dorsal skin of rats. Triamcinolone (10 mg/kg, p.o.) also showed an inhibitory effect on the carrageenin-induced granulation model. Tranilast (50-400 mg/kg, p.o.) dose-dependently inhibited the enhancement of capillary permeability induced by the Ca ionophore A23187, bradykinin and xanthine oxidase. Moreover, tranilast (30 and 300 microM) suppressed superoxide production induced by FMLP in human neutrophils, but did not act as a superoxide scavenger. Considering that hypertrophic scar and keloid are conditions characterized by abnormal cell proliferation and excessive collagen accumulation accompanied with itch and pain, these results suggest that tranilast is useful as a therapeutic drug for hypertrophic scars and keloids.
我们研究了曲尼司特对大鼠角叉菜胶诱导的肉芽组织生长以及炎性介质诱导的毛细血管通透性增加的影响。在角叉菜胶诱导的肉芽组织模型中，曲尼司特（50或100 - 200毫克/千克，口服）显著且剂量依赖性地降低了肉芽组织的重量和羟脯氨酸含量。然而，曲尼司特对大鼠局部创伤背部皮肤的愈合天数没有影响。曲安奈德（10毫克/千克，口服）对角叉菜胶诱导的肉芽组织模型也有抑制作用。曲尼司特（50 - 400毫克/千克，口服）剂量依赖性地抑制了钙离子载体A23187、缓激肽和黄嘌呤氧化酶诱导的毛细血管通透性增强。此外，曲尼司特（30和300微摩尔）抑制了人中性粒细胞中FMLP诱导的超氧化物产生，但不作为超氧化物清除剂。考虑到增生性瘢痕和瘢痕疙瘩是以异常细胞增殖、过度胶原积累并伴有瘙痒和疼痛为特征的病症，这些结果表明曲尼司特作为增生性瘢痕和瘢痕疙瘩的治疗药物是有用的。
